1nvm

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{{STRUCTURE_1nvm| PDB=1nvm | SCENE= }}
{{STRUCTURE_1nvm| PDB=1nvm | SCENE= }}
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'''Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate'''
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===Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate===
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==Overview==
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The crystal structure of the bifunctional enzyme 4-hydroxy-2-ketovalerate aldolase (DmpG)/acylating acetaldehyde dehydrogenase (DmpF), which is involved in the bacterial degradation of toxic aromatic compounds, has been determined by multiwavelength anomalous dispersion (MAD) techniques and refined to 1.7-A resolution. Structures of the two polypeptides represent a previously unrecognized subclass of metal-dependent aldolases, and of a CoA-dependent dehydrogenase. The structure reveals a mixed state of NAD+ binding to the DmpF protomer. Domain movements associated with cofactor binding in the DmpF protomer may be correlated with channeling and activity at the DmpG protomer. In the presence of NAD+ a 29-A-long sequestered tunnel links the two active sites. Two barriers are visible along the tunnel and suggest control points for the movement of the reactive and volatile acetaldehyde intermediate between the two active sites.
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The line below this paragraph, {{ABSTRACT_PUBMED_12764229}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12764229 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12764229}}
==About this Structure==
==About this Structure==
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[[Category: Sequestered tunnel]]
[[Category: Sequestered tunnel]]
[[Category: Substrate channeling]]
[[Category: Substrate channeling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:01:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:44:06 2008''

Revision as of 05:44, 28 July 2008

Image:1nvm.png

Template:STRUCTURE 1nvm

Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate

Template:ABSTRACT PUBMED 12764229

About this Structure

1NVM is a Protein complex structure of sequences from Pseudomonas sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate., Manjasetty BA, Powlowski J, Vrielink A, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6992-7. Epub 2003 May 22. PMID:12764229

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