1rea

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{{STRUCTURE_1rea| PDB=1rea | SCENE= }}
{{STRUCTURE_1rea| PDB=1rea | SCENE= }}
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'''STRUCTURE OF THE RECA PROTEIN-ADP COMPLEX'''
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===STRUCTURE OF THE RECA PROTEIN-ADP COMPLEX===
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==Overview==
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The recA protein catalyses the ATP-driven homologous pairing and strand exchange of DNA molecules. It is an allosteric enzyme: the ATPase activity is DNA-dependent, and ATP-bound recA protein has a high affinity for DNA, whereas the ADP-bound form has a low affinity. In the absence of ATP hydrolysis, recA protein can still promote homologous pairing, apparently through the formation of a triple-stranded intermediate. The exact role of ATP hydrolysis is not clear, but it presumably drives the triplex intermediate towards products. Here we determine the position of bound ADP diffused into the recA crystal. We show that only the phosphates are bound in the same way as in other NTPases containing the G/AXXXXGKT/S motif. We propose that recA protein may change its conformation upon ATP hydrolysis in a manner analogous to one such protein, the p21 protein from the ras oncogene. A model is presented to account for the allosteric stimulation of DNA binding by ATP. The mechanism by which nucleoside triphosphate hydrolysis is coupled to the binding of another ligand in recA protein and p21 may be typical of the large class of NTPases containing this conserved motif.
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The line below this paragraph, {{ABSTRACT_PUBMED_1731253}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1731253 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1731253}}
==About this Structure==
==About this Structure==
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[[Category: Homologous recombination]]
[[Category: Homologous recombination]]
[[Category: Self-cleavage stimulation]]
[[Category: Self-cleavage stimulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:23:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:45:27 2008''

Revision as of 05:45, 28 July 2008

Image:1rea.png

Template:STRUCTURE 1rea

STRUCTURE OF THE RECA PROTEIN-ADP COMPLEX

Template:ABSTRACT PUBMED 1731253

About this Structure

1REA is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the recA protein-ADP complex., Story RM, Steitz TA, Nature. 1992 Jan 23;355(6358):374-6. PMID:1731253

Page seeded by OCA on Mon Jul 28 08:45:27 2008

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