3bod

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{{STRUCTURE_3bod| PDB=3bod | SCENE= }}
{{STRUCTURE_3bod| PDB=3bod | SCENE= }}
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'''Structure of mouse beta-neurexin 1'''
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===Structure of mouse beta-neurexin 1===
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==Overview==
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Presynaptic neurexins (NRXs) bind to postsynaptic neuroligins (NLs) to form Ca(2+)-dependent complexes that bridge neural synapses. beta-NRXs bind NLs through their LNS domains, which contain a single site of alternative splicing (splice site 4) giving rise to two isoforms: +4 and Delta. We present crystal structures of the Delta isoforms of the LNS domains from beta-NRX1 and beta-NRX2, crystallized in the presence of Ca(2+) ions. The Ca(2+)-binding site is disordered in the beta-NRX2 structure, but the 1.7 A beta-NRX1 structure reveals a single Ca(2+) ion, approximately 12 A from the splice insertion site, with one coordinating ligand donated by a glutamic acid from an adjacent beta-NRX1 molecule. NMR studies of beta-NRX1+4 show that the insertion sequence is unstructured, and remains at least partially disordered in complex with NL. These results raise the possibility that beta-NRX insertion sequence 4 may function in roles independent of neuroligin binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_18334216}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18334216 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18334216}}
==About this Structure==
==About this Structure==
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[[Category: Neurexin1d]]
[[Category: Neurexin1d]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:57:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:47:34 2008''

Revision as of 05:47, 28 July 2008

Image:3bod.png

Template:STRUCTURE 3bod

Structure of mouse beta-neurexin 1

Template:ABSTRACT PUBMED 18334216

About this Structure

3BOD is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal Structures of beta-Neurexin 1 and beta-Neurexin 2 Ectodomains and Dynamics of Splice Insertion Sequence 4., Koehnke J, Jin X, Trbovic N, Katsamba PS, Brasch J, Ahlsen G, Scheiffele P, Honig B, Palmer AG 3rd, Shapiro L, Structure. 2008 Mar;16(3):410-21. PMID:18334216

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