1wq1

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{{STRUCTURE_1wq1| PDB=1wq1 | SCENE= }}
{{STRUCTURE_1wq1| PDB=1wq1 | SCENE= }}
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'''RAS-RASGAP COMPLEX'''
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===RAS-RASGAP COMPLEX===
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==Overview==
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The three-dimensional structure of the complex between human H-Ras bound to guanosine diphosphate and the guanosine triphosphatase (GTPase)-activating domain of the human GTPase-activating protein p120GAP (GAP-334) in the presence of aluminum fluoride was solved at a resolution of 2.5 angstroms. The structure shows the partly hydrophilic and partly hydrophobic nature of the communication between the two molecules, which explains the sensitivity of the interaction toward both salts and lipids. An arginine side chain (arginine-789) of GAP-334 is supplied into the active site of Ras to neutralize developing charges in the transition state. The switch II region of Ras is stabilized by GAP-334, thus allowing glutamine-61 of Ras, mutation of which activates the oncogenic potential, to participate in catalysis. The structural arrangement in the active site is consistent with a mostly associative mechanism of phosphoryl transfer and provides an explanation for the activation of Ras by glycine-12 and glutamine-61 mutations. Glycine-12 in the transition state mimic is within van der Waals distance of both arginine-789 of GAP-334 and glutamine-61 of Ras, and even its mutation to alanine would disturb the arrangements of residues in the transition state.
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{{ABSTRACT_PUBMED_9219684}}
==About this Structure==
==About this Structure==
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[[Category: Signal transduction]]
[[Category: Signal transduction]]
[[Category: Transition state]]
[[Category: Transition state]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:59:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:48:51 2008''

Revision as of 05:48, 28 July 2008

Image:1wq1.png

Template:STRUCTURE 1wq1

RAS-RASGAP COMPLEX

Template:ABSTRACT PUBMED 9219684

About this Structure

1WQ1 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants., Scheffzek K, Ahmadian MR, Kabsch W, Wiesmuller L, Lautwein A, Schmitz F, Wittinghofer A, Science. 1997 Jul 18;277(5324):333-8. PMID:9219684

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