2p6j

From Proteopedia

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{{STRUCTURE_2p6j| PDB=2p6j | SCENE= }}
{{STRUCTURE_2p6j| PDB=2p6j | SCENE= }}
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'''Full-sequence computational design and solution structure of a thermostable protein variant'''
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===Full-sequence computational design and solution structure of a thermostable protein variant===
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==Overview==
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Computational protein design procedures were applied to the redesign of the entire sequence of a 51 amino acid residue protein, Drosophila melanogaster engrailed homeodomain. Various sequence optimization algorithms were compared and two resulting designed sequences were experimentally evaluated. The two sequences differ by 11 mutations and share 22% and 24% sequence identity with the wild-type protein. Both computationally designed proteins were considerably more stable than the naturally occurring protein, with midpoints of thermal denaturation greater than 99 degrees C. The solution structure was determined for one of the two sequences using multidimensional heteronuclear NMR spectroscopy, and the structure was found to closely match the original design template scaffold.
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(as it appears on PubMed at http://www.pubmed.gov), where 17628593 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17628593}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P6J OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P6J OCA].
==Reference==
==Reference==
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[[Category: Helix-turn-helix]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:29:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:51:32 2008''

Revision as of 05:51, 28 July 2008

Image:2p6j.png

Template:STRUCTURE 2p6j

Full-sequence computational design and solution structure of a thermostable protein variant

Template:ABSTRACT PUBMED 17628593

About this Structure

Full experimental information is available from OCA.

Reference

Full-sequence computational design and solution structure of a thermostable protein variant., Shah PS, Hom GK, Ross SA, Lassila JK, Crowhurst KA, Mayo SL, J Mol Biol. 2007 Sep 7;372(1):1-6. Epub 2007 Jun 16. PMID:17628593

Page seeded by OCA on Mon Jul 28 08:51:32 2008

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