2i46

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{{STRUCTURE_2i46| PDB=2i46 | SCENE= }}
{{STRUCTURE_2i46| PDB=2i46 | SCENE= }}
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'''Crystal structure of human TPP1'''
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===Crystal structure of human TPP1===
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==Overview==
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Telomeres were originally defined as chromosome caps that prevent the natural ends of linear chromosomes from undergoing deleterious degradation and fusion events. POT1 (protection of telomeres) protein binds the single-stranded G-rich DNA overhangs at human chromosome ends and suppresses unwanted DNA repair activities. TPP1 is a previously identified binding partner of POT1 that has been proposed to form part of a six-protein shelterin complex at telomeres. Here, the crystal structure of a domain of human TPP1 reveals an oligonucleotide/oligosaccharide-binding fold that is structurally similar to the beta-subunit of the telomere end-binding protein of a ciliated protozoan, suggesting that TPP1 is the missing beta-subunit of human POT1 protein. Telomeric DNA end-binding proteins have generally been found to inhibit rather than stimulate the action of the chromosome end-replicating enzyme, telomerase. In contrast, we find that TPP1 and POT1 form a complex with telomeric DNA that increases the activity and processivity of the human telomerase core enzyme. We propose that POT1-TPP1 switches from inhibiting telomerase access to the telomere, as a component of shelterin, to serving as a processivity factor for telomerase during telomere extension.
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(as it appears on PubMed at http://www.pubmed.gov), where 17237768 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17237768}}
==About this Structure==
==About this Structure==
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[[Category: Pot1 binding]]
[[Category: Pot1 binding]]
[[Category: Tpp1]]
[[Category: Tpp1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:02:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:51:58 2008''

Revision as of 05:52, 28 July 2008

Image:2i46.png

Template:STRUCTURE 2i46

Crystal structure of human TPP1

Template:ABSTRACT PUBMED 17237768

About this Structure

2I46 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The POT1-TPP1 telomere complex is a telomerase processivity factor., Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M, Nature. 2007 Feb 1;445(7127):506-10. Epub 2007 Jan 21. PMID:17237768

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