2afj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2afj.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2afj.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2afj| PDB=2afj | SCENE= }}
{{STRUCTURE_2afj| PDB=2afj | SCENE= }}
-
'''SPRY domain-containing SOCS box protein 2 (SSB-2)'''
+
===SPRY domain-containing SOCS box protein 2 (SSB-2)===
-
==Overview==
+
<!--
-
The four mammalian SPRY domain-containing SOCS box proteins (SSB-1 to SSB-4) are characterized by a C-terminal SOCS box and a central SPRY domain. We have determined the first SPRY-domain structure, as part of SSB-2, by NMR. This domain adopts a novel fold consisting of a beta-sandwich structure formed by two four-stranded antiparallel beta-sheets with a unique topology. We demonstrate that SSB-1, SSB-2 and SSB-4, but not SSB-3, bind prostate apoptosis response protein-4 (Par-4). Mutational analysis of SSB-2 loop regions identified conserved structural determinants for its interaction with Par-4 and the hepatocyte growth factor receptor, c-Met. Mutations in analogous loop regions of pyrin and midline-1 SPRY domains have been shown to cause Mediterranean fever and Opitz syndrome, respectively. Our findings provide a template for SPRY-domain structure and an insight into the mechanism of SPRY-protein interaction.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16369487}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16369487 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16369487}}
==About this Structure==
==About this Structure==
-
2AFJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFJ OCA].
+
2AFJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFJ OCA].
==Reference==
==Reference==
Line 33: Line 37:
[[Category: Zhang, J G.]]
[[Category: Zhang, J G.]]
[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:59:26 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:52:34 2008''

Revision as of 05:52, 28 July 2008

Image:2afj.png

Template:STRUCTURE 2afj

SPRY domain-containing SOCS box protein 2 (SSB-2)

Template:ABSTRACT PUBMED 16369487

About this Structure

2AFJ is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues., Masters SL, Yao S, Willson TA, Zhang JG, Palmer KR, Smith BJ, Babon JJ, Nicola NA, Norton RS, Nicholson SE, Nat Struct Mol Biol. 2006 Jan;13(1):77-84. Epub 2005 Dec 20. PMID:16369487

Page seeded by OCA on Mon Jul 28 08:52:34 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2afj"
Personal tools