2ady

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[[Image:2ady.gif|left|200px]]
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{{Seed}}
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[[Image:2ady.png|left|200px]]
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{{STRUCTURE_2ady| PDB=2ady | SCENE= }}
{{STRUCTURE_2ady| PDB=2ady | SCENE= }}
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'''Structural Basis of DNA Recognition by p53 Tetramers (complex IV)'''
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===Structural Basis of DNA Recognition by p53 Tetramers (complex IV)===
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==Overview==
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The tumor-suppressor protein p53 is among the most effective of the cell's natural defenses against cancer. In response to cellular stress, p53 binds as a tetramer to diverse DNA targets containing two decameric half-sites, thereby activating the expression of genes involved in cell-cycle arrest or apoptosis. Here we present high-resolution crystal structures of sequence-specific complexes between the core domain of human p53 and different DNA half-sites. In all structures, four p53 molecules self-assemble on two DNA half-sites to form a tetramer that is a dimer of dimers, stabilized by protein-protein and base-stacking interactions. The protein-DNA interface varies as a function of the specific base sequence in correlation with the measured binding affinities of the complexes. The new data establish a structural framework for understanding the mechanisms of specificity, affinity, and cooperativity of DNA binding by p53 and suggest a model for its regulation by regions outside the sequence-specific DNA binding domain.
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The line below this paragraph, {{ABSTRACT_PUBMED_16793544}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16793544 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16793544}}
==About this Structure==
==About this Structure==
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[[Category: Shakked, Z.]]
[[Category: Shakked, Z.]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:55:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:57:34 2008''

Revision as of 05:57, 28 July 2008

Image:2ady.png

Template:STRUCTURE 2ady

Structural Basis of DNA Recognition by p53 Tetramers (complex IV)

Template:ABSTRACT PUBMED 16793544

About this Structure

2ADY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of DNA recognition by p53 tetramers., Kitayner M, Rozenberg H, Kessler N, Rabinovich D, Shaulov L, Haran TE, Shakked Z, Mol Cell. 2006 Jun 23;22(6):741-53. PMID:16793544

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