1y8y

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[[Image:1y8y.gif|left|200px]]
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{{Seed}}
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[[Image:1y8y.png|left|200px]]
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{{STRUCTURE_1y8y| PDB=1y8y | SCENE= }}
{{STRUCTURE_1y8y| PDB=1y8y | SCENE= }}
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'''Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor'''
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===Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor===
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==Overview==
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The protein structure guided design of a series of pyrazolo[1,5-a]pyrimidines with high potency for human cyclin-dependent kinase 2 (CDK2) is described. Some examples were shown to inhibit the growth of human colon tumour cells, were equipotent for CDK1 and were selective against GSK-3beta and other kinases.
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(as it appears on PubMed at http://www.pubmed.gov), where 15686876 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15686876}}
==About this Structure==
==About this Structure==
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[[Category: Pyrazolopyrimidine inhibitor]]
[[Category: Pyrazolopyrimidine inhibitor]]
[[Category: Serine/threonine protein kinase]]
[[Category: Serine/threonine protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:01:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:58:42 2008''

Revision as of 05:58, 28 July 2008

Image:1y8y.png

Template:STRUCTURE 1y8y

Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor

Template:ABSTRACT PUBMED 15686876

About this Structure

1Y8Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2., Williamson DS, Parratt MJ, Bower JF, Moore JD, Richardson CM, Dokurno P, Cansfield AD, Francis GL, Hebdon RJ, Howes R, Jackson PS, Lockie AM, Murray JB, Nunns CL, Powles J, Robertson A, Surgenor AE, Torrance CJ, Bioorg Med Chem Lett. 2005 Feb 15;15(4):863-7. PMID:15686876

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