This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ct9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ct9.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ct9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ct9| PDB=2ct9 | SCENE= }}
{{STRUCTURE_2ct9| PDB=2ct9 | SCENE= }}
-
'''The crystal structure of calcineurin B homologous proein 1 (CHP1)'''
+
===The crystal structure of calcineurin B homologous proein 1 (CHP1)===
-
==Overview==
+
<!--
-
Calcineurin B homologous protein 1 (CHP1), also known as p22, is a calcium-binding EF-hand protein that plays a role in membrane trafficking. It binds to multiple effector proteins, including Na(+)/H(+) exchangers, a serine/threonine kinase, and calcineurin, potentially modulating their function. The crystal structure of calcium-bound CHP1 from rat has been determined at 2.2 Angstroms of resolution. The molecule has a compact alpha-helical structure containing four EF-hands. The overall folding topology of the protein is similar to that of the regulatory B subunit of calcineurin and to that of calcium- and integrin-binding protein. The calcium ion is coordinated in typical fashion in the third and fourth EF-hands, but the first and second EF-hands contain no calcium ion. The first EF-hand is maintained by internal interactions, and the second EF-hand is stabilized by hydrophobic interactions. CHP1 contains a hydrophobic pocket on the opposite side of the protein to the EF-hands that has been implicated in ligand binding.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15987692}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15987692 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15987692}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Calcium binding protein]]
[[Category: Calcium binding protein]]
[[Category: Ef-hand]]
[[Category: Ef-hand]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:00:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:00:21 2008''

Revision as of 06:00, 28 July 2008

Image:2ct9.png

Template:STRUCTURE 2ct9

The crystal structure of calcineurin B homologous proein 1 (CHP1)

Template:ABSTRACT PUBMED 15987692

About this Structure

2CT9 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural characterization of calcineurin B homologous protein 1., Naoe Y, Arita K, Hashimoto H, Kanazawa H, Sato M, Shimizu T, J Biol Chem. 2005 Sep 16;280(37):32372-8. Epub 2005 Jun 29. PMID:15987692

Page seeded by OCA on Mon Jul 28 09:00:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ct9"
Personal tools