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3bk6

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{{STRUCTURE_3bk6| PDB=3bk6 | SCENE= }}
{{STRUCTURE_3bk6| PDB=3bk6 | SCENE= }}
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'''Crystal structure of a core domain of stomatin from Pyrococcus horikoshii'''
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===Crystal structure of a core domain of stomatin from Pyrococcus horikoshii===
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==Overview==
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Stomatin is a major integral membrane protein of human erythrocytes, the absence of which is associated with a form of hemolytic anemia known as hereditary stomatocytosis. However, the function of stomatin is not fully understood. An open reading frame, PH1511, from the hyperthermophilic archaeon Pyrococcus horikoshii encodes p-stomatin, a prokaryotic stomatin. Here, we report the first crystal structure of a stomatin ortholog, the core domain of the p-stomatin PH1511p (residues 56-234 of PH1511p, designated as PhSto(CD)). PhSto(CD) forms a novel homotrimeric structure. Three alpha/beta domains form a triangle of about 50 A on each side, and three alpha-helical segments of about 60 A in length extend from the apexes of the triangle. The alpha/beta domain of PhSto(CD) is partly similar in structure to the band-7 domain of mouse flotillin-2. While the alpha/beta domain is relatively rigid, the alpha-helical segment shows conformational flexibility, adapting to the neighboring environment. One alpha-helical segment forms an anti-parallel coiled coil with another alpha-helical segment from a symmetry-related molecule. The alpha-helical segment shows a heptad repeat pattern, and mainly hydrophobic residues form a coiled-coil interface. According to chemical cross-linking experiments, PhSto(CD) would be able to assemble into an oligomeric form. The coiled-coil fold observed in the crystal probably contributes to self-association.
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(as it appears on PubMed at http://www.pubmed.gov), where 18182167 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18182167}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystal structure of a core domain of stomatin from Pyrococcus horikoshii Illustrates a novel trimeric and coiled-coil fold., Yokoyama H, Fujii S, Matsui I, J Mol Biol. 2008 Feb 22;376(3):868-78. Epub 2008 Jan 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18182167 18182167]
Crystal structure of a core domain of stomatin from Pyrococcus horikoshii Illustrates a novel trimeric and coiled-coil fold., Yokoyama H, Fujii S, Matsui I, J Mol Biol. 2008 Feb 22;376(3):868-78. Epub 2008 Jan 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18182167 18182167]
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Molecular structure of a novel membrane protease specific for a stomatin homolog from the hyperthermophilic archaeon Pyrococcus horikoshii., Yokoyama H, Matsui E, Akiba T, Harata K, Matsui I, J Mol Biol. 2006 May 12;358(4):1152-64. Epub 2006 Mar 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16574150 16574150]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Trimer]]
[[Category: Trimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:52:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:02:19 2008''

Revision as of 06:02, 28 July 2008

Image:3bk6.png

Template:STRUCTURE 3bk6

Crystal structure of a core domain of stomatin from Pyrococcus horikoshii

Template:ABSTRACT PUBMED 18182167

About this Structure

3BK6 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Crystal structure of a core domain of stomatin from Pyrococcus horikoshii Illustrates a novel trimeric and coiled-coil fold., Yokoyama H, Fujii S, Matsui I, J Mol Biol. 2008 Feb 22;376(3):868-78. Epub 2008 Jan 8. PMID:18182167

Molecular structure of a novel membrane protease specific for a stomatin homolog from the hyperthermophilic archaeon Pyrococcus horikoshii., Yokoyama H, Matsui E, Akiba T, Harata K, Matsui I, J Mol Biol. 2006 May 12;358(4):1152-64. Epub 2006 Mar 9. PMID:16574150

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