1od1

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{{STRUCTURE_1od1| PDB=1od1 | SCENE= }}
{{STRUCTURE_1od1| PDB=1od1 | SCENE= }}
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'''ENDOTHIAPEPSIN PD135,040 COMPLEX'''
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===ENDOTHIAPEPSIN PD135,040 COMPLEX===
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==Overview==
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The crystal structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 has been anisotropically refined to a resolution of 1.37 A. The structure of this inhibitor complex is in agreement with previous structures of endothiapepsin gem-diol inhibitor complexes that have been used to develop proposed catalytic mechanisms. However, the increase in resolution over previous structures confirms the presence of a number of short hydrogen bonds within the active site that are likely to play an important role in the catalytic mechanism. The presence of low-barrier hydrogen bonds was indicated in a previous one-dimensional H NMR spectrum.
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(as it appears on PubMed at http://www.pubmed.gov), where 12777758 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12777758}}
==About this Structure==
==About this Structure==
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[[Category: Wood, S P.]]
[[Category: Wood, S P.]]
[[Category: Hydrolase,acid proteinase,inhibitor,aspartyl protease]]
[[Category: Hydrolase,acid proteinase,inhibitor,aspartyl protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:41:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:04:09 2008''

Revision as of 06:04, 28 July 2008

Image:1od1.png

Template:STRUCTURE 1od1

ENDOTHIAPEPSIN PD135,040 COMPLEX

Template:ABSTRACT PUBMED 12777758

About this Structure

1OD1 is a Protein complex structure of sequences from Cryphonectria parasitica. Full crystallographic information is available from OCA.

Reference

The structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 at 1.37 A., Coates L, Erskine PT, Mall S, Williams PA, Gill RS, Wood SP, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):978-81. Epub 2003, May 23. PMID:12777758

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