1oun

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{{STRUCTURE_1oun| PDB=1oun | SCENE= }}
{{STRUCTURE_1oun| PDB=1oun | SCENE= }}
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'''CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)'''
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===CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)===
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==Overview==
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Nuclear transport factor 2 (NTF2) facilitates protein transport into the nucleus and interacts with both the small Ras-like GTPase Ran and nucleoporin p62. We have determined the structure of bacterially expressed rat NTF2 at 1.6 angstroms resolution using X-ray crystallography. The NTF2 polypeptide chain forms an alpha + beta barrel that opens at one end to form a distinctive hydrophobic cavity and its fold is homologous to that of scytalone dehydratase. The NTF2 hydrophobic cavity is a candidate for a potential binding site for other proteins involved in nuclear import such as Ran and nucleoporin p62. In addition, the hydrophobic cavity contains a putative catalytic Asp-His pair, which raises the possibility of an unanticipated enzymatic activity of the molecule that may have implications for the molecular mechanism of nuclear protein import.
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(as it appears on PubMed at http://www.pubmed.gov), where 8757804 is the PubMed ID number.
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==About this Structure==
==About this Structure==
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[[Category: Nuclear transport protein]]
[[Category: Nuclear transport protein]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:06:28 2008''

Revision as of 06:06, 28 July 2008

Image:1oun.png

Template:STRUCTURE 1oun

CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)

Template:ABSTRACT PUBMED 8757804

About this Structure

1OUN is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2)., Bullock TL, Clarkson WD, Kent HM, Stewart M, J Mol Biol. 1996 Jul 19;260(3):422-31. PMID:8757804

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