2d5i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2d5i.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2d5i.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2d5i| PDB=2d5i | SCENE= }}
{{STRUCTURE_2d5i| PDB=2d5i | SCENE= }}
-
'''The crystal structure of AzoR (Azo Reductase) from Escherichia coli'''
+
===The crystal structure of AzoR (Azo Reductase) from Escherichia coli===
-
==Overview==
+
<!--
-
The crystal structure of AzoR (azoreductase) has been determined in complex with FMN for two different crystal forms at 1.8 and 2.2 A resolution. AzoR is an oxidoreductase isolated from Escherichia coli as a protein responsible for the degradation of azo compounds. This enzyme is an FMN-dependent NADH-azoreductase and catalyzes the reductive cleavage of azo groups by a ping-pong mechanism. The structure suggests that AzoR acts in a homodimeric state forming the two identical catalytic sites to which both monomers contribute. The structure revealed that each monomer of AzoR has a flavodoxin-like structure, without the explicit overall amino acid sequence homology. Superposition of the structures from the two different crystal forms revealed the conformational change and suggested a mechanism for accommodating substrates of different size. Furthermore, comparison of the active site structure with that of NQO1 complexed with substrates provides clues to the possible substrate-binding mechanism of AzoR.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16684776}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16684776 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16684776}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Azo reductase]]
[[Category: Azo reductase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:44:37 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:08:03 2008''

Revision as of 06:08, 28 July 2008

Image:2d5i.png

Template:STRUCTURE 2d5i

The crystal structure of AzoR (Azo Reductase) from Escherichia coli

Template:ABSTRACT PUBMED 16684776

About this Structure

2D5I is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of AzoR from Escherichia coli. An oxidereductase conserved in microorganisms., Ito K, Nakanishi M, Lee WC, Sasaki H, Zenno S, Saigo K, Kitade Y, Tanokura M, J Biol Chem. 2006 Jul 21;281(29):20567-76. Epub 2006 May 9. PMID:16684776

Page seeded by OCA on Mon Jul 28 09:08:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2d5i"
Personal tools