1yrg

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{{STRUCTURE_1yrg| PDB=1yrg | SCENE= }}
{{STRUCTURE_1yrg| PDB=1yrg | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF RNA1P: A NEW FOLD FOR A GTPASE-ACTIVATING PROTEIN'''
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===THE CRYSTAL STRUCTURE OF RNA1P: A NEW FOLD FOR A GTPASE-ACTIVATING PROTEIN===
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==Overview==
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rna1p is the Schizosaccharomyces pombe ortholog of the mammalian GTPase-activating protein (GAP) of Ran. Both proteins are essential for nuclear transport. Here, we report the crystal structure of rna1p at 2.66 A resolution. It contains 11 leucine-rich repeats that adopt the nonglobular shape of a crescent, bearing no resemblance to RhoGAP or RasGAP. The invariant residues of RanGAP form a contiguous surface, strongly indicating the Ran-binding interface. Alanine mutations identify Arg-74 as a critical residue for GTP hydrolysis. In contrast to RasGAP and RhoGAP, Arg-74 could be substituted by lysine and contributed significantly to the binding of Ran. Therefore, we suggest a GAP mechanism for rna1p, which constitutes a variation of the arginine finger mechanism found for Ras GAP and RhoGAP.
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(as it appears on PubMed at http://www.pubmed.gov), where 10394366 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10394366}}
==About this Structure==
==About this Structure==
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[[Category: Rna1p]]
[[Category: Rna1p]]
[[Category: Twinning]]
[[Category: Twinning]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:41:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:11:33 2008''

Revision as of 06:11, 28 July 2008

Image:1yrg.png

Template:STRUCTURE 1yrg

THE CRYSTAL STRUCTURE OF RNA1P: A NEW FOLD FOR A GTPASE-ACTIVATING PROTEIN

Template:ABSTRACT PUBMED 10394366

About this Structure

1YRG is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

The crystal structure of rna1p: a new fold for a GTPase-activating protein., Hillig RC, Renault L, Vetter IR, Drell T 4th, Wittinghofer A, Becker J, Mol Cell. 1999 Jun;3(6):781-91. PMID:10394366

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