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2juo

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{{STRUCTURE_2juo| PDB=2juo | SCENE= }}
{{STRUCTURE_2juo| PDB=2juo | SCENE= }}
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'''GABPa OST domain'''
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===GABPa OST domain===
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==Overview==
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Using NMR spectroscopy, we identified and characterized a previously unrecognized structured domain near the N-terminus (residues 35-121) of the ETS family transcription factor GABP alpha. The monomeric domain folds as a five-stranded beta-sheet crossed by a distorted helix. Although globally resembling ubiquitin, the GABP alpha fragment differs in its secondary structure topology and thus appears to represent a new protein fold that we term the OST (On-SighT) domain. The surface of the GABP alpha OST domain contains two predominant clusters of negatively-charged residues suggestive of electrostatically driven interactions with positively-charged partner proteins. Following a best-candidate approach to identify such a partner, we demonstrated through NMR-monitored titrations and glutathione S-transferase pulldown assays that the OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300. This provides a direct structural link between GABP and a central component of the transcriptional machinery.
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(as it appears on PubMed at http://www.pubmed.gov), where 18295234 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18295234}}
==About this Structure==
==About this Structure==
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2JUO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA].
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2JUO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUO OCA].
==Reference==
==Reference==
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[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:14:10 2008''

Revision as of 06:14, 28 July 2008

Image:2juo.png

Template:STRUCTURE 2juo

GABPa OST domain

Template:ABSTRACT PUBMED 18295234

About this Structure

2JUO is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha., Kang HS, Nelson ML, Mackereth CD, Scharpf M, Graves BJ, McIntosh LP, J Mol Biol. 2008 Mar 28;377(3):636-46. Epub 2008 Jan 30. PMID:18295234

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