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2fbe

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{{STRUCTURE_2fbe| PDB=2fbe | SCENE= }}
{{STRUCTURE_2fbe| PDB=2fbe | SCENE= }}
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'''Crystal Structure of the PRYSPRY-domain'''
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===Crystal Structure of the PRYSPRY-domain===
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==Overview==
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We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded and a 6-stranded antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds to the concave surface of a donor molecule, which represents a putative interaction site. Mutations in the PRYSPRY domains of Pyrin, which are responsible for familial Mediterranean fever, map on the putative PRYSPRY interaction site.
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(as it appears on PubMed at http://www.pubmed.gov), where 16364311 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16364311}}
==About this Structure==
==About this Structure==
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[[Category: Dimer]]
[[Category: Dimer]]
[[Category: Jellyroll beta-sandwich fold]]
[[Category: Jellyroll beta-sandwich fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:41:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:15:33 2008''

Revision as of 06:15, 28 July 2008

Image:2fbe.png

Template:STRUCTURE 2fbe

Crystal Structure of the PRYSPRY-domain

Template:ABSTRACT PUBMED 16364311

About this Structure

2FBE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the PRYSPRY-domain: implications for autoinflammatory diseases., Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG, FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:16364311

Page seeded by OCA on Mon Jul 28 09:15:33 2008

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