1yhp

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{{STRUCTURE_1yhp| PDB=1yhp | SCENE= }}
{{STRUCTURE_1yhp| PDB=1yhp | SCENE= }}
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'''Solution Structure of Ca2+-free DdCAD-1'''
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===Solution Structure of Ca2+-free DdCAD-1===
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==Overview==
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DdCAD-1 is a novel Ca(2+)-dependent cell adhesion molecule that lacks a hydrophobic signal peptide and a transmembrane domain. DdCAD-1 is expressed by the social amoeba Dictyostelium discoideum at the onset of development. It is synthesized as a soluble protein and then transported to the plasma membrane by contractile vacuoles. Here we describe the novel features of the solution structures of Ca(2+)-free and Ca(2+)-bound monomeric DdCAD-1. DdCAD-1 contains two beta-sandwich domains, belonging to the betagamma-crystallin and immunoglobulin fold classes, respectively. Whereas the N-terminal domain has a major role in homophilic binding, the C-terminal domain tethers the protein to the cell membrane. From structural and mutational analyses, we propose a model for the Ca(2+)-bound DdCAD-1 dimer as a basis for understanding DdCAD-1-mediated cell-cell adhesion at the molecular level. Our results provide new insights into Ca(2+)-dependent mechanisms for cell-cell adhesion.
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(as it appears on PubMed at http://www.pubmed.gov), where 17057715 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17057715}}
==About this Structure==
==About this Structure==
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1YHP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHP OCA].
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1YHP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHP OCA].
==Reference==
==Reference==
Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17057715 17057715]
Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17057715 17057715]
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(1)H, (13)C and (15)N resonance assignments of Ca(2+)-free DdCAD-1: a Ca(2+)-dependent cell-cell adhesion molecule., Lin Z, Huang H, Siu CH, Yang D, J Biomol NMR. 2004 Nov;30(3):375-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15756470 15756470]
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Ddcad-1]]
[[Category: Ddcad-1]]
[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:19:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:16:17 2008''

Revision as of 06:16, 28 July 2008

Image:1yhp.png

Template:STRUCTURE 1yhp

Solution Structure of Ca2+-free DdCAD-1

Template:ABSTRACT PUBMED 17057715

About this Structure

1YHP is a Single protein structure of sequence from Dictyostelium discoideum. Full experimental information is available from OCA.

Reference

Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:17057715

(1)H, (13)C and (15)N resonance assignments of Ca(2+)-free DdCAD-1: a Ca(2+)-dependent cell-cell adhesion molecule., Lin Z, Huang H, Siu CH, Yang D, J Biomol NMR. 2004 Nov;30(3):375-6. PMID:15756470

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