1t1n

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[[Image:1t1n.jpg|left|200px]]
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{{Seed}}
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[[Image:1t1n.png|left|200px]]
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{{STRUCTURE_1t1n| PDB=1t1n | SCENE= }}
{{STRUCTURE_1t1n| PDB=1t1n | SCENE= }}
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'''CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN'''
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===CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN===
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==Overview==
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As new structural data have become available, somewhat contrasting explanations of the Root effect in fish haemoglobins (Hb) have been provided. Hb 1 of the Antarctic fish Trematomus newnesi has a nearly pH-independent oxygen affinity, in spite of 95 % sequence identity with Hb 1 of Trematomus (previously named Pagothenia) bernacchii that has a strong Root effect. Here, the 2.2 A R-state structure of Trematomus newnesi Hb 1 is presented. The structure is similar to that of Root effect fish Hbs from Spot and T. bernacchii, suggesting that the differences in the pH dependence cannot be related to the modulation of the R-state. In comparison to T. bernacchii Hb 1, the role of the three mutations Thr41 (C6)alpha--&gt;Ile, Ala97 (G3)alpha--&gt;Ser and His41 (C7)beta--&gt;Tyr at the alpha1beta2-interface is discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_10222199}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10222199 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10222199}}
==About this Structure==
==About this Structure==
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[[Category: Hemoglobin]]
[[Category: Hemoglobin]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:23:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:16:31 2008''

Revision as of 06:16, 28 July 2008

Image:1t1n.png

Template:STRUCTURE 1t1n

CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN

Template:ABSTRACT PUBMED 10222199

About this Structure

1T1N is a Protein complex structure of sequences from Trematomus newnesi. Full crystallographic information is available from OCA.

Reference

Crystal structure of Trematomus newnesi haemoglobin re-opens the root effect question., Mazzarella L, D'Avino R, di Prisco G, Savino C, Vitagliano L, Moody PC, Zagari A, J Mol Biol. 1999 Apr 16;287(5):897-906. PMID:10222199

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