1yse

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[[Image:1yse.gif|left|200px]]
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{{STRUCTURE_1yse| PDB=1yse | SCENE= }}
{{STRUCTURE_1yse| PDB=1yse | SCENE= }}
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'''Solution structure of the MAR-binding domain of SATB1'''
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===Solution structure of the MAR-binding domain of SATB1===
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==Overview==
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SATB1 is a transcriptional regulator controlling the gene expression that is essential in the maturation of the immune T-cell. SATB1 binds to the nuclear matrix attachment regions of DNA, where it recruits histone deacetylase and represses transcription through a local chromatin remodeling. Here we determined the solution structure of the matrix attachment region-binding domain, possessing similarity to the CUT DNA-binding domain, of human SATB1 by NMR spectroscopy. The structure consists of five alpha-helices, in which the N-terminal four are arranged similarly to the four-helix structure of the CUT domain of hepatocyte nuclear factor 6alpha. By an NMR chemical shift perturbation analysis and by surface plasmon resonance analyses of SATB1 mutant proteins, an interface for DNA binding was revealed to be located at the third helix and the surrounding regions. Surface plasmon resonance experiments using groove-specific binding drugs and methylated DNAs indicated that the domain recognizes DNA from the major groove side. These observations suggested that SATB1 possesses a DNA-binding mode similar to that of the POU-specific DNA-binding domain, which is known to share structural similarity to the four-helix CUT domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 16371359 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16371359}}
==About this Structure==
==About this Structure==
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1YSE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSE OCA].
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1YSE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSE OCA].
==Reference==
==Reference==
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[[Category: Dna-binding domain]]
[[Category: Dna-binding domain]]
[[Category: T-cell development]]
[[Category: T-cell development]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:43:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:19:19 2008''

Revision as of 06:19, 28 July 2008

Image:1yse.png

Template:STRUCTURE 1yse

Solution structure of the MAR-binding domain of SATB1

Template:ABSTRACT PUBMED 16371359

About this Structure

1YSE is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure and DNA-binding mode of the matrix attachment region-binding domain of the transcription factor SATB1 that regulates the T-cell maturation., Yamaguchi H, Tateno M, Yamasaki K, J Biol Chem. 2006 Feb 24;281(8):5319-27. Epub 2005 Dec 21. PMID:16371359

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