1qmq

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{{Seed}}
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{{STRUCTURE_1qmq| PDB=1qmq | SCENE= }}
{{STRUCTURE_1qmq| PDB=1qmq | SCENE= }}
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'''OPTICAL DETECTION OF CYTOCHROME P450 BY SENSITIZER-LINKED SUBSTRATES'''
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===OPTICAL DETECTION OF CYTOCHROME P450 BY SENSITIZER-LINKED SUBSTRATES===
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==Overview==
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The ability to detect, characterize, and manipulate specific biomolecules in complex media is critical for understanding metabolic processes. Particularly important targets are oxygenases (cytochromes P450) involved in drug metabolism and many disease states, including liver and kidney dysfunction, neurological disorders, and cancer. We have found that Ru photosensitizers linked to P450 substrates specifically recognize submicromolar cytochrome P450(cam) in the presence of other heme proteins. In the P450:Ru-substrate conjugates, energy transfer to the heme dramatically accelerates the Ru-luminescence decay. The crystal structure of a P450(cam):Ru-adamantyl complex reveals access to the active center via a channel whose depth (Ru-Fe distance is 21 A) is virtually the same as that extracted from an analysis of the energy-transfer kinetics. Suitably constructed libraries of sensitizer-linked substrates could be employed to probe the steric and electronic properties of buried active sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 10557259 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10557259}}
==About this Structure==
==About this Structure==
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[[Category: Gray, H B.]]
[[Category: Gray, H B.]]
[[Category: Ru-substrate]]
[[Category: Ru-substrate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:27:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:22:56 2008''

Revision as of 06:23, 28 July 2008

Image:1qmq.png

Template:STRUCTURE 1qmq

OPTICAL DETECTION OF CYTOCHROME P450 BY SENSITIZER-LINKED SUBSTRATES

Template:ABSTRACT PUBMED 10557259

About this Structure

1QMQ is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Optical detection of cytochrome P450 by sensitizer-linked substrates., Dmochowski IJ, Crane BR, Wilker JJ, Winkler JR, Gray HB, Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):12987-90. PMID:10557259

Page seeded by OCA on Mon Jul 28 09:22:56 2008

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