1ow5

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{{STRUCTURE_1ow5| PDB=1ow5 | SCENE= }}
{{STRUCTURE_1ow5| PDB=1ow5 | SCENE= }}
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'''NMR structure of the Saccharomyces cerevisiae SAM (Sterile Alpha Motif) domain'''
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===NMR structure of the Saccharomyces cerevisiae SAM (Sterile Alpha Motif) domain===
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==Overview==
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Ste11 is a MAPKKK from Saccharomyces cerevisiae that helps mediate the response to mating pheromone and the ability to thrive in high-salt environments. These diverse functions are facilitated by a direct interaction between the SAM domain of Ste11 with the SAM domain of its regulatory partner, Ste50. We have solved the NMR structure of the Ste11 SAM domain (PDB 1OW5), which reveals a compact, five alpha-helix bundle and a high degree of structural similarity to the Polyhomeotic SAM domain. The combined study of Ste11 SAM rotational correlation times and crosslinking to Ste50-SAM has suggested a mode through which Ste11-SAM oligomerizes and selectively associates with Ste50-SAM. To probe homotypic and heterotypic interations, Ste11-SAM variants each containing a substitution of a surface-exposed hydrophobic residue were constructed. An I59R variant of Ste11-SAM, disrupted binding to Ste50-SAM in vitro. Yeast expressing full-length Ste11-I59R could neither respond to mating pheromone nor thrive in high salt media-demonstrating that the interaction between Ste11 and Ste50 SAM domains is a prerequisite for key signal transduction events.
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{{ABSTRACT_PUBMED_15327964}}
==About this Structure==
==About this Structure==
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1OW5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OW5 OCA].
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1OW5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OW5 OCA].
==Reference==
==Reference==
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[[Category: Scm domain]]
[[Category: Scm domain]]
[[Category: Ste50 regulator]]
[[Category: Ste50 regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:20:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:27:34 2008''

Revision as of 06:27, 28 July 2008

Image:1ow5.png

Template:STRUCTURE 1ow5

NMR structure of the Saccharomyces cerevisiae SAM (Sterile Alpha Motif) domain

Template:ABSTRACT PUBMED 15327964

About this Structure

1OW5 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

The solution structure of the S.cerevisiae Ste11 MAPKKK SAM domain and its partnership with Ste50., Kwan JJ, Warner N, Pawson T, Donaldson LW, J Mol Biol. 2004 Sep 10;342(2):681-93. PMID:15327964

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