3bep

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{{STRUCTURE_3bep| PDB=3bep | SCENE= }}
{{STRUCTURE_3bep| PDB=3bep | SCENE= }}
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'''Structure of a sliding clamp on DNA'''
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===Structure of a sliding clamp on DNA===
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==Overview==
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The structure of the E. coli beta clamp polymerase processivity factor has been solved in complex with primed DNA. Interestingly, the clamp directly binds the DNA duplex and also forms a crystal contact with the ssDNA template strand, which binds into the protein-binding pocket of the clamp. We demonstrate that these clamp-DNA interactions function in clamp loading, perhaps by inducing the ring to close around DNA. Clamp binding to template ssDNA may also serve to hold the clamp at a primed site after loading or during switching of multiple factors on the clamp. Remarkably, the DNA is highly tilted as it passes through the beta ring. The pronounced 22 degrees angle of DNA through beta may enable DNA to switch between multiple factors bound to a single clamp simply by alternating from one protomer of the ring to the other.
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{{ABSTRACT_PUBMED_18191219}}
==About this Structure==
==About this Structure==
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[[Category: Transcription/dna complex]]
[[Category: Transcription/dna complex]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:41:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:27:32 2008''

Revision as of 06:27, 28 July 2008

Image:3bep.png

Template:STRUCTURE 3bep

Structure of a sliding clamp on DNA

Template:ABSTRACT PUBMED 18191219

About this Structure

3BEP is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of a sliding clamp on DNA., Georgescu RE, Kim SS, Yurieva O, Kuriyan J, Kong XP, O'Donnell M, Cell. 2008 Jan 11;132(1):43-54. PMID:18191219

Page seeded by OCA on Mon Jul 28 09:27:32 2008

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