2r03

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{{STRUCTURE_2r03| PDB=2r03 | SCENE= }}
{{STRUCTURE_2r03| PDB=2r03 | SCENE= }}
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'''Crystal Structure of ALIX/AIP1 in complex with the YPDL Late Domain'''
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===Crystal Structure of ALIX/AIP1 in complex with the YPDL Late Domain===
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==Overview==
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Retrovirus budding requires short peptide motifs (late domains) located within the viral Gag protein that function by recruiting cellular factors. The YPX(n)L late domains of HIV and other lentiviruses recruit the protein ALIX (also known as AIP1), which also functions in vesicle formation at the multivesicular body and in the abscission stage of cytokinesis. Here, we report the crystal structures of ALIX in complex with the YPX(n)L late domains from HIV-1 and EIAV. The two distinct late domains bind at the same site on the ALIX V domain but adopt different conformations that allow them to make equivalent contacts. Binding studies and functional assays verified the importance of key interface residues and revealed that binding affinities are tuned by context-dependent effects. These results reveal how YPX(n)L late domains recruit ALIX to facilitate virus budding and how ALIX can bind YPX(n)L sequences with both n = 1 and n = 3.
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(as it appears on PubMed at http://www.pubmed.gov), where 18066081 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18066081}}
==About this Structure==
==About this Structure==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:00:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:30:42 2008''

Revision as of 06:30, 28 July 2008

Image:2r03.png

Template:STRUCTURE 2r03

Crystal Structure of ALIX/AIP1 in complex with the YPDL Late Domain

Template:ABSTRACT PUBMED 18066081

About this Structure

2R03 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and functional studies of ALIX interactions with YPX(n)L late domains of HIV-1 and EIAV., Zhai Q, Fisher RD, Chung HY, Myszka DG, Sundquist WI, Hill CP, Nat Struct Mol Biol. 2008 Jan;15(1):43-9. Epub 2007 Dec 9. PMID:18066081

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