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2nmv

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[[Image:2nmv.gif|left|200px]]
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{{STRUCTURE_2nmv| PDB=2nmv | SCENE= }}
{{STRUCTURE_2nmv| PDB=2nmv | SCENE= }}
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'''Damage detection by the UvrABC pathway: Crystal structure of UvrB bound to fluorescein-adducted DNA'''
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===Damage detection by the UvrABC pathway: Crystal structure of UvrB bound to fluorescein-adducted DNA===
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==Overview==
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UvrB is the damage recognition element of the highly conserved UvrABC pathway that functions in the removal of bulky DNA adducts. Pivotal to this is the formation of a damage detection complex that relies on the ability of UvrB to locate and sequester diverse lesions. Whilst structures of UvrB bound to DNA have recently been reported, none address the issue of lesion recognition. Here, we describe the crystal structure of UvrB bound to a pentanucleotide containing a single fluorescein-adducted thymine that reveals a unique mechanism for damage detection entirely dependent on the exclusion of lesions larger than an undamaged nucleotide.
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(as it appears on PubMed at http://www.pubmed.gov), where 17097086 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17097086}}
==About this Structure==
==About this Structure==
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[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: T-fluorescein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:38:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:31:06 2008''

Revision as of 06:31, 28 July 2008

Image:2nmv.png

Template:STRUCTURE 2nmv

Damage detection by the UvrABC pathway: Crystal structure of UvrB bound to fluorescein-adducted DNA

Template:ABSTRACT PUBMED 17097086

About this Structure

2NMV is a Protein complex structure of sequences from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Damage detection by the UvrABC pathway: crystal structure of UvrB bound to fluorescein-adducted DNA., Waters TR, Eryilmaz J, Geddes S, Barrett TE, FEBS Lett. 2006 Nov 27;580(27):6423-7. Epub 2006 Nov 3. PMID:17097086

Page seeded by OCA on Mon Jul 28 09:31:06 2008

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