1tey

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{{STRUCTURE_1tey| PDB=1tey | SCENE= }}
{{STRUCTURE_1tey| PDB=1tey | SCENE= }}
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'''NMR structure of human histone chaperone, ASF1A'''
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===NMR structure of human histone chaperone, ASF1A===
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==Overview==
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Asf1 is a conserved histone chaperone implicated in nucleosome assembly, transcriptional silencing, and the cellular response to DNA damage. We solved the NMR solution structure of the N-terminal functional domain of the human Asf1a isoform, and we identified by NMR chemical shift mapping a surface of Asf1a that binds the C-terminal helix of histone H3. This binding surface forms a highly conserved hydrophobic groove surrounded by charged residues. Mutations within this binding site decreased the affinity of Asf1a for the histone H3/H4 complex in vitro, and the same mutations in the homologous yeast protein led to transcriptional silencing defects, DNA damage sensitivity, and thermosensitive growth. We have thus obtained direct experimental evidence of the mode of binding between a histone and one of its chaperones and genetic data suggesting that this interaction is important in both the DNA damage response and transcriptional silencing.
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{{ABSTRACT_PUBMED_15840725}}
==About this Structure==
==About this Structure==
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1TEY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TEY OCA].
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1TEY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TEY OCA].
==Reference==
==Reference==
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[[Category: Beta-sandwich]]
[[Category: Beta-sandwich]]
[[Category: Distorted immunoglobulin-like]]
[[Category: Distorted immunoglobulin-like]]
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Revision as of 06:38, 28 July 2008

Image:1tey.png

Template:STRUCTURE 1tey

NMR structure of human histone chaperone, ASF1A

Template:ABSTRACT PUBMED 15840725

About this Structure

1TEY is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural basis for the interaction of Asf1 with histone H3 and its functional implications., Mousson F, Lautrette A, Thuret JY, Agez M, Courbeyrette R, Amigues B, Becker E, Neumann JM, Guerois R, Mann C, Ochsenbein F, Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5975-80. Epub 2005 Apr 19. PMID:15840725

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