2d2a

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{{STRUCTURE_2d2a| PDB=2d2a | SCENE= }}
{{STRUCTURE_2d2a| PDB=2d2a | SCENE= }}
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'''Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters'''
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===Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters===
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==Overview==
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IscA and SufA are paralogous proteins that play crucial roles in the biosynthesis of Fe-S clusters, perhaps through a mechanism involving transient Fe-S cluster formation. We have determined the crystal structure of E. coli SufA at 2.7A resolution. SufA exists as a homodimer, in contrast to the tetrameric organization of IscA. Furthermore, a C-terminal segment containing two essential cysteine residues (Cys-Gly-Cys), which is disordered in the IscA structure, is clearly visible in one molecule (the alpha1 subunit) of the SufA homodimer. Although this segment is disordered in the other molecule (the alpha2 subunit), computer modeling of this segment based on the well-defined conformation of alpha1 subunit suggests that the four cysteine residues (Cys114 and Cys116 in each subunit) in the Cys-Gly-Cys motif are positioned in close proximity at the dimer interface. The arrangement of these cysteines together with the nearby Glu118 in SufA dimer may allow coordination of an Fe-S cluster and/or an Fe atom.
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(as it appears on PubMed at http://www.pubmed.gov), where 16298366 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16298366}}
==About this Structure==
==About this Structure==
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[[Category: Sufa]]
[[Category: Sufa]]
[[Category: Yadr]]
[[Category: Yadr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:34:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:38:52 2008''

Revision as of 06:38, 28 July 2008

Image:2d2a.png

Template:STRUCTURE 2d2a

Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters

Template:ABSTRACT PUBMED 16298366

About this Structure

2D2A is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of Escherichia coli SufA involved in biosynthesis of iron-sulfur clusters: implications for a functional dimer., Wada K, Hasegawa Y, Gong Z, Minami Y, Fukuyama K, Takahashi Y, FEBS Lett. 2005 Dec 5;579(29):6543-8. Epub 2005 Nov 15. PMID:16298366

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