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2uvy

From Proteopedia

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[[Image:2uvy.jpg|left|200px]]
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{{STRUCTURE_2uvy| PDB=2uvy | SCENE= }}
{{STRUCTURE_2uvy| PDB=2uvy | SCENE= }}
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'''STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH METHYL-(4-(9H-PURIN-6-YL)-BENZYL)-AMINE'''
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===STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH METHYL-(4-(9H-PURIN-6-YL)-BENZYL)-AMINE===
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==Overview==
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6-phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein. An elaborated lead compound showed cell growth inhibition and effects on cellular signaling pathways characteristic of PKB inhibition.
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(as it appears on PubMed at http://www.pubmed.gov), where 17451235 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17451235}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Transferase/inhibitor complex]]
[[Category: Transferase/inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:30:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:40:31 2008''

Revision as of 06:40, 28 July 2008

Image:2uvy.png

Template:STRUCTURE 2uvy

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH METHYL-(4-(9H-PURIN-6-YL)-BENZYL)-AMINE

Template:ABSTRACT PUBMED 17451235

About this Structure

2UVY is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design., Donald A, McHardy T, Rowlands MG, Hunter LJ, Davies TG, Berdini V, Boyle RG, Aherne GW, Garrett MD, Collins I, J Med Chem. 2007 May 17;50(10):2289-92. Epub 2007 Apr 24. PMID:17451235

Page seeded by OCA on Mon Jul 28 09:40:31 2008

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