1uel

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[[Image:1uel.gif|left|200px]]
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{{STRUCTURE_1uel| PDB=1uel | SCENE= }}
{{STRUCTURE_1uel| PDB=1uel | SCENE= }}
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'''Solution structure of ubiquitin-like domain of hHR23B complexed with ubiquitin-interacting motif of proteasome subunit S5a'''
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===Solution structure of ubiquitin-like domain of hHR23B complexed with ubiquitin-interacting motif of proteasome subunit S5a===
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==Overview==
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Ubiquitination, a modification in which single or multiple ubiquitin molecules are attached to a protein, serves signaling functions that control several cellular processes. The ubiquitination signal is recognized by downstream effectors, many of which carry a ubiquitin-interacting motif (UIM). Such interactions can be modulated by regulators carrying a ubiquitin-like (UbL) domain, which binds UIM by mimicking ubiquitination. Of them, HR23B regulates the proteasomal targeting of ubiquitinated substrates, DNA repair factors, and other proteins. Here we report the structure of the UIM of the proteasome subunit S5a bound to the UbL domain of HR23B. The UbL domain presents one hydrophobic and two polar contact sites for interaction with UIM. The residues in these contact sites are well conserved in ubiquitin, but ubiquitin also presents a histidine at the interface. The pH-dependent protonation of this residue interferes with the access of ubiquitin to the UIM and the ubiquitin-associated domain (UBA), and its mutation to a smaller residue increases the affinity of ubiquitin for UIM.
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The line below this paragraph, {{ABSTRACT_PUBMED_14585839}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14585839 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14585839}}
==About this Structure==
==About this Structure==
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1UEL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEL OCA].
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1UEL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEL OCA].
==Reference==
==Reference==
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[[Category: Ubl]]
[[Category: Ubl]]
[[Category: Uim]]
[[Category: Uim]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:06:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:42:14 2008''

Revision as of 06:42, 28 July 2008

Image:1uel.png

Template:STRUCTURE 1uel

Solution structure of ubiquitin-like domain of hHR23B complexed with ubiquitin-interacting motif of proteasome subunit S5a

Template:ABSTRACT PUBMED 14585839

About this Structure

1UEL is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B., Fujiwara K, Tenno T, Sugasawa K, Jee JG, Ohki I, Kojima C, Tochio H, Hiroaki H, Hanaoka F, Shirakawa M, J Biol Chem. 2004 Feb 6;279(6):4760-7. Epub 2003 Oct 29. PMID:14585839

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