This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1nsh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1nsh.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1nsh.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1nsh| PDB=1nsh | SCENE= }}
{{STRUCTURE_1nsh| PDB=1nsh | SCENE= }}
-
'''Solution Structure of Rabbit apo-S100A11 (19 models)'''
+
===Solution Structure of Rabbit apo-S100A11 (19 models)===
-
==Overview==
+
<!--
-
S100A11 is a homodimeric EF-hand calcium binding protein that undergoes a calcium-induced conformational change and interacts with the phospholipid binding protein annexin I to coordinate membrane association. In this work, the solution structure of apo-S100A11 has been determined by NMR spectroscopy to uncover the details of its calcium-induced structural change. Apo-S100A11 forms a tight globular structure having a near antiparallel orientation of helices III and IV in calcium binding site II. Further, helices I and IV, and I and I', form a more closed arrangement than observed in other apo-S100 proteins. This helix arrangement in apo-S100A11 partially buries residues in helices I (P3, E11, A15), III (V55, R58, M59), and IV (A86, C87, S90) and the linker (A45, F46), which are required for interaction with annexin I in the calcium-bound state. In apo-S100A11, this results in a "masked" binding surface that prevents annexin I binding but is uncovered upon calcium binding.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12842051}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12842051 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12842051}}
==About this Structure==
==About this Structure==
-
1NSH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NSH OCA].
+
1NSH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NSH OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Helix-loop-helix]]
[[Category: Helix-loop-helix]]
[[Category: S100a11]]
[[Category: S100a11]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:55:26 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:43:51 2008''

Revision as of 06:43, 28 July 2008

Image:1nsh.png

Template:STRUCTURE 1nsh

Solution Structure of Rabbit apo-S100A11 (19 models)

Template:ABSTRACT PUBMED 12842051

About this Structure

1NSH is a Single protein structure of sequence from Oryctolagus cuniculus. Full experimental information is available from OCA.

Reference

Unmasking the annexin I interaction from the structure of Apo-S100A11., Dempsey AC, Walsh MP, Shaw GS, Structure. 2003 Jul;11(7):887-97. PMID:12842051

Page seeded by OCA on Mon Jul 28 09:43:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nsh"
Personal tools