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1nsh

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[[Image:1nsh.gif|left|200px]]
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{{STRUCTURE_1nsh| PDB=1nsh | SCENE= }}
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'''Solution Structure of Rabbit apo-S100A11 (19 models)'''
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===Solution Structure of Rabbit apo-S100A11 (19 models)===
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==Overview==
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S100A11 is a homodimeric EF-hand calcium binding protein that undergoes a calcium-induced conformational change and interacts with the phospholipid binding protein annexin I to coordinate membrane association. In this work, the solution structure of apo-S100A11 has been determined by NMR spectroscopy to uncover the details of its calcium-induced structural change. Apo-S100A11 forms a tight globular structure having a near antiparallel orientation of helices III and IV in calcium binding site II. Further, helices I and IV, and I and I', form a more closed arrangement than observed in other apo-S100 proteins. This helix arrangement in apo-S100A11 partially buries residues in helices I (P3, E11, A15), III (V55, R58, M59), and IV (A86, C87, S90) and the linker (A45, F46), which are required for interaction with annexin I in the calcium-bound state. In apo-S100A11, this results in a "masked" binding surface that prevents annexin I binding but is uncovered upon calcium binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_12842051}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12842051 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12842051}}
==About this Structure==
==About this Structure==
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1NSH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NSH OCA].
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1NSH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NSH OCA].
==Reference==
==Reference==
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[[Category: Helix-loop-helix]]
[[Category: Helix-loop-helix]]
[[Category: S100a11]]
[[Category: S100a11]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:55:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:43:51 2008''

Revision as of 06:43, 28 July 2008

Image:1nsh.png

Template:STRUCTURE 1nsh

Solution Structure of Rabbit apo-S100A11 (19 models)

Template:ABSTRACT PUBMED 12842051

About this Structure

1NSH is a Single protein structure of sequence from Oryctolagus cuniculus. Full experimental information is available from OCA.

Reference

Unmasking the annexin I interaction from the structure of Apo-S100A11., Dempsey AC, Walsh MP, Shaw GS, Structure. 2003 Jul;11(7):887-97. PMID:12842051

Page seeded by OCA on Mon Jul 28 09:43:51 2008

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