1wug

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1wug.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1wug.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1wug| PDB=1wug | SCENE= }}
{{STRUCTURE_1wug| PDB=1wug | SCENE= }}
-
'''complex structure of PCAF bromodomain with small chemical ligand NP1'''
+
===complex structure of PCAF bromodomain with small chemical ligand NP1===
-
==Overview==
+
<!--
-
Development of drug resistance from mutations in the targeted viral proteins leads to continuation of viral production by chronically infected cells, contributing to HIV-mediated immune dysfunction. Targeting a host cell protein essential for viral reproduction, rather than a viral protein, may minimize the viral drug resistance problem as observed with HIV protease inhibitors. We report here the development of a novel class of N1-aryl-propane-1,3-diamine compounds using a structure-based approach that selectively inhibit the activity of the bromodomain of the human transcriptional co-activator PCAF, of which association with the HIV trans-activator Tat is essential for transcription and replication of the integrated HIV provirus.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15724976}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15724976 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15724976}}
==About this Structure==
==About this Structure==
-
1WUG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUG OCA].
+
1WUG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUG OCA].
==Reference==
==Reference==
Line 35: Line 39:
[[Category: Histone-acetyltransferase]]
[[Category: Histone-acetyltransferase]]
[[Category: Nmr-structure]]
[[Category: Nmr-structure]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:09:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:45:43 2008''

Revision as of 06:45, 28 July 2008

Image:1wug.png

Template:STRUCTURE 1wug

complex structure of PCAF bromodomain with small chemical ligand NP1

Template:ABSTRACT PUBMED 15724976

About this Structure

1WUG is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Selective small molecules blocking HIV-1 Tat and coactivator PCAF association., Zeng L, Li J, Muller M, Yan S, Mujtaba S, Pan C, Wang Z, Zhou MM, J Am Chem Soc. 2005 Mar 2;127(8):2376-7. PMID:15724976

Page seeded by OCA on Mon Jul 28 09:45:43 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wug"
Personal tools