1rfv

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[[Image:1rfv.jpg|left|200px]]
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{{STRUCTURE_1rfv| PDB=1rfv | SCENE= }}
{{STRUCTURE_1rfv| PDB=1rfv | SCENE= }}
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'''Crystal structure of pyridoxal kinase complexed with ADP'''
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===Crystal structure of pyridoxal kinase complexed with ADP===
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==Overview==
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To understand the processes involved in the catalytic mechanism of pyridoxal kinase (PLK),1 we determined the crystal structures of PLK.AMP-PCP-pyridoxamine, PLK.ADP.PLP, and PLK.ADP complexes. Comparisons of these structures have revealed that PLK exhibits different conformations during its catalytic process. After the binding of AMP-PCP (an analogue that replaced ATP) and pyridoxamine to PLK, this enzyme retains a conformation similar to that of the PLK.ATP complex. The distance between the reacting groups of the two substrates is 5.8 A apart, indicating that the position of ATP is not favorable to spontaneous transfer of its phosphate group. However, the structure of PLK.ADP.PLP complex exhibited significant changes in both the conformation of the enzyme and the location of the ligands at the active site. Therefore, it appears that after binding of both substrates, the enzyme-substrate complex requires changes in the protein structure to enable the transfer of the phosphate group from ATP to vitamin B(6). Furthermore, a conformation of the enzyme-substrate complex before the transition state of the enzymatic reaction was also hypothesized.
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The line below this paragraph, {{ABSTRACT_PUBMED_14722069}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14722069 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14722069}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Conformational changes in the reaction of pyridoxal kinase., Li MH, Kwok F, Chang WR, Liu SQ, Lo SC, Zhang JP, Jiang T, Liang DC, J Biol Chem. 2004 Apr 23;279(17):17459-65. Epub 2004 Jan 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14722069 14722069]
Conformational changes in the reaction of pyridoxal kinase., Li MH, Kwok F, Chang WR, Liu SQ, Lo SC, Zhang JP, Jiang T, Liang DC, J Biol Chem. 2004 Apr 23;279(17):17459-65. Epub 2004 Jan 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14722069 14722069]
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Crystal structure of brain pyridoxal kinase, a novel member of the ribokinase superfamily., Li MH, Kwok F, Chang WR, Lau CK, Zhang JP, Lo SC, Jiang T, Liang DC, J Biol Chem. 2002 Nov 29;277(48):46385-90. Epub 2002 Sep 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12235162 12235162]
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Crystallization and preliminary crystallographic studies of pyridoxal kinase from sheep brain., Li MH, Kwok F, An XM, Chang WR, Lau CK, Zhang JP, Liu SQ, Leung YC, Jiang T, Liang DC, Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1479-81. Epub 2002, Aug 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12198308 12198308]
[[Category: Ovis aries]]
[[Category: Ovis aries]]
[[Category: Pyridoxal kinase]]
[[Category: Pyridoxal kinase]]
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[[Category: Liang, D C.]]
[[Category: Liang, D C.]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:26:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:47:10 2008''

Revision as of 06:47, 28 July 2008

Image:1rfv.png

Template:STRUCTURE 1rfv

Crystal structure of pyridoxal kinase complexed with ADP

Template:ABSTRACT PUBMED 14722069

About this Structure

1RFV is a Single protein structure of sequence from Ovis aries. Full crystallographic information is available from OCA.

Reference

Conformational changes in the reaction of pyridoxal kinase., Li MH, Kwok F, Chang WR, Liu SQ, Lo SC, Zhang JP, Jiang T, Liang DC, J Biol Chem. 2004 Apr 23;279(17):17459-65. Epub 2004 Jan 13. PMID:14722069

Crystal structure of brain pyridoxal kinase, a novel member of the ribokinase superfamily., Li MH, Kwok F, Chang WR, Lau CK, Zhang JP, Lo SC, Jiang T, Liang DC, J Biol Chem. 2002 Nov 29;277(48):46385-90. Epub 2002 Sep 15. PMID:12235162

Crystallization and preliminary crystallographic studies of pyridoxal kinase from sheep brain., Li MH, Kwok F, An XM, Chang WR, Lau CK, Zhang JP, Liu SQ, Leung YC, Jiang T, Liang DC, Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1479-81. Epub 2002, Aug 23. PMID:12198308

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