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1m9o

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(New page: 200px<br /><applet load="1m9o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m9o" /> '''NMR structure of the first Zinc Binding doma...)
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Revision as of 19:08, 20 November 2007

Image:1m9o.gif

1m9o

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NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11

Overview

Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding, domains of the form Cys-X8-Cys-X5-Cys-X3-His. These domains are required, for rapid degradation of tumor necrosis factor (TNF) and other mRNAs, through the interaction with AU-rich elements in their 3'-untranslated, regions. The three-dimensional solution structure of the first domain was, determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. The core structure is, disk-like with a diameter of approximately 25 A and a width of, approximately 12 A. This structure provides a basis for evaluating the, role of individual residues for structural stability and for nucleic acid, binding.

About this Structure

1M9O is a Single protein structure of sequence from Mus musculus with ZN as ligand. Full crystallographic information is available from OCA.

Reference

A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure., Amann BT, Worthington MT, Berg JM, Biochemistry. 2003 Jan 14;42(1):217-21. PMID:12515557

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