1ul2

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[[Image:1ul2.jpg|left|200px]]
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{{STRUCTURE_1ul2| PDB=1ul2 | SCENE= }}
{{STRUCTURE_1ul2| PDB=1ul2 | SCENE= }}
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'''Solution Conformation of alpha-Conotoxin GIC'''
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===Solution Conformation of alpha-Conotoxin GIC===
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==Overview==
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Alpha-conotoxin GIC is a 16-residue peptide isolated from the venom of the cone snail Conus geographus. Alpha-conotoxin GIC potently blocks the alpha3beta2 subtype of human nicotinic acetylcholine receptor, showing a high selectivity for neuronal versus muscle subtype [McIntosh, Dowell, Watkins, Garrett, Yoshikami, and Olivera (2002) J. Biol. Chem. 277, 33610-33615]. We have now determined the three-dimensional solution structure of alpha-conotoxin GIC by NMR spectroscopy. The structure of alpha-conotoxin GIC is well defined with backbone and heavy atom root mean square deviations (residues 2-16) of 0.53 A and 0.96 A respectively. Structure and surface comparison of alpha-conotoxin GIC with the other alpha4/7 subfamily conotoxins reveals unique structural aspects of alpha-conotoxin GIC. In particular, the structural comparison between alpha-conotoxins GIC and MII indicates molecular features that may confer their similar receptor specificity profile, as well as those that provide the unique binding characteristics of alpha-conotoxin GIC.
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(as it appears on PubMed at http://www.pubmed.gov), where 14992691 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14992691}}
==About this Structure==
==About this Structure==
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1UL2 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL2 OCA].
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1UL2 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL2 OCA].
==Reference==
==Reference==
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[[Category: C-terminal amidation]]
[[Category: C-terminal amidation]]
[[Category: Two disulfide bond]]
[[Category: Two disulfide bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:22:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:51:32 2008''

Revision as of 06:51, 28 July 2008

Image:1ul2.png

Template:STRUCTURE 1ul2

Solution Conformation of alpha-Conotoxin GIC

Template:ABSTRACT PUBMED 14992691

About this Structure

1UL2 is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem J. 2004 Jun 1;380(Pt 2):347-52. PMID:14992691

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