2g9l

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[[Image:2g9l.jpg|left|200px]]
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{{STRUCTURE_2g9l| PDB=2g9l | SCENE= }}
{{STRUCTURE_2g9l| PDB=2g9l | SCENE= }}
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'''The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction'''
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===The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction===
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==Overview==
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We have applied NMR spectroscopy to determine the high-resolution structure of gaegurin 4, a 37-residue antimicrobial peptide from Rana rugosa, under varying hydrophobic conditions. Even in 100% H2O, gaegurin 4 contains a nascent turn near its C-terminal Rana box. Under a more hydrophobic condition it forms two amphipathic helices, one long encompassing residues 2-23 and the other consisting of residues 25-34, similar to what has been observed in cecropin A. Functional implication of the helix-breaking kink at Gly24 in gaegurin 4 was investigated by preparing several analogs. Based upon the current and previous results, we propose a novel seaanemone-like ion pore-forming model for gaegurin 4.
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(as it appears on PubMed at http://www.pubmed.gov), where 17141187 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17141187}}
==About this Structure==
==About this Structure==
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2G9L is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9L OCA].
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2G9L is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9L OCA].
==Reference==
==Reference==
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[[Category: Han, K H.]]
[[Category: Han, K H.]]
[[Category: Amphipathic helix]]
[[Category: Amphipathic helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:51:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:52:08 2008''

Revision as of 06:52, 28 July 2008

Image:2g9l.png

Template:STRUCTURE 2g9l

The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction

Template:ABSTRACT PUBMED 17141187

About this Structure

2G9L is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4., Chi SW, Kim JS, Kim DH, Lee SH, Park YH, Han KH, Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-7. Epub 2006 Nov 27. PMID:17141187

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