1xox

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[[Image:1xox.gif|left|200px]]
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{{Seed}}
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[[Image:1xox.png|left|200px]]
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{{STRUCTURE_1xox| PDB=1xox | SCENE= }}
{{STRUCTURE_1xox| PDB=1xox | SCENE= }}
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'''SOLUTION STRUCTURE OF HUMAN SURVIVIN'''
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===SOLUTION STRUCTURE OF HUMAN SURVIVIN===
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==Overview==
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NMR studies of the antiapoptotic protein survivin have been used to determine the homodimer interface of the protein in solution and to identify residues of the protein that interact with Smac/Diablo. In solution, survivin(1-120) forms a bow-tie-shaped dimer whose interface is composed of its N-terminal residues as well as residues connecting its BIR domain to the C-terminal alpha helix. The solution structure resolves the controversy regarding the two possible dimer interfaces for survivin observed in X-ray crystal structures. The structural basis for the interaction between survivin and Smac/Diablo was also investigated. When Smac/Diablo or N-terminal Smac/Diablo peptide analogues are added to a solution of survivin, specific residues near alpha4 and beta3 are perturbed. NMR experiments indicate that the peptides bind across the third beta-strand of survivin in a manner similar to the way Smac/Diablo peptides bind to the BIR3 domain of X-linked IAP (XIAP).
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The line below this paragraph, {{ABSTRACT_PUBMED_15628841}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15628841 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15628841}}
==About this Structure==
==About this Structure==
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1XOX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOX OCA].
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1XOX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOX OCA].
==Reference==
==Reference==
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[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Bir domain]]
[[Category: Bir domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:18:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:54:42 2008''

Revision as of 06:54, 28 July 2008

Image:1xox.png

Template:STRUCTURE 1xox

SOLUTION STRUCTURE OF HUMAN SURVIVIN

Template:ABSTRACT PUBMED 15628841

About this Structure

1XOX is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of human survivin and its binding interface with Smac/Diablo., Sun C, Nettesheim D, Liu Z, Olejniczak ET, Biochemistry. 2005 Jan 11;44(1):11-7. PMID:15628841

Page seeded by OCA on Mon Jul 28 09:54:42 2008

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