1txy

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[[Image:1txy.gif|left|200px]]
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{{STRUCTURE_1txy| PDB=1txy | SCENE= }}
{{STRUCTURE_1txy| PDB=1txy | SCENE= }}
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'''E. coli PriB'''
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===E. coli PriB===
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==Overview==
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Maintenance of genome stability following DNA damage requires origin-independent reinitiation of DNA replication at repaired replication forks. In E. coli, PriA, PriB, PriC, and DnaT play critical roles in recognizing repaired replication forks and reloading the replisome onto the template to reinitiate DNA replication. Here, we report the 2.0 A resolution crystal structure of E. coli PriB, revealing a dimer that consists of a single structural domain formed by two oligonucleotide/oligosaccharide binding (OB) folds. Structural similarity of PriB to single-stranded DNA binding proteins reveals insights into its mechanisms of DNA binding. The structure further establishes a putative protein interaction surface that may contribute to the role of PriB in primosome assembly by facilitating interactions with PriA and DnaT. This is the first high-resolution structure of a protein involved in oriC-independent replisome loading and provides unique insight into mechanisms of replication restart in E. coli.
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(as it appears on PubMed at http://www.pubmed.gov), where 15530361 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15530361}}
==About this Structure==
==About this Structure==
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[[Category: Dimer]]
[[Category: Dimer]]
[[Category: Ob fold]]
[[Category: Ob fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:58:28 2008''

Revision as of 06:58, 28 July 2008

Image:1txy.png

Template:STRUCTURE 1txy

E. coli PriB

Template:ABSTRACT PUBMED 15530361

About this Structure

1TXY is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of PriB, a component of the Escherichia coli replication restart primosome., Lopper M, Holton JM, Keck JL, Structure. 2004 Nov;12(11):1967-75. PMID:15530361

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