2hjv

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[[Image:2hjv.gif|left|200px]]
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{{STRUCTURE_2hjv| PDB=2hjv | SCENE= }}
{{STRUCTURE_2hjv| PDB=2hjv | SCENE= }}
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'''Structure of the second domain (residues 207-368) of the Bacillus subtilis YxiN protein'''
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===Structure of the second domain (residues 207-368) of the Bacillus subtilis YxiN protein===
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==Overview==
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The Bacillus subtilis RNA helicase YxiN is a modular three-domain protein. The first two domains form a conserved helicase core that couples an ATPase activity to an RNA duplex-destabilization activity, while the third domain recognizes a stem-loop of 23S ribosomal RNA with high affinity and specificity. The structure of the second domain, amino-acid residues 207-368, has been solved to 1.95 A resolution, revealing a parallel alphabeta-fold. The crystallographic asymmetric unit contains two protomers; superposition shows that they differ substantially in two segments of peptide that overlap the conserved helicase sequence motifs V and VI, while the remainder of the domain is isostructural. The conformational variability of these segments suggests that induced fit is intrinsic to the recognition of ligands (ATP and RNA) and the coupling of the ATPase activity to conformational changes.
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(as it appears on PubMed at http://www.pubmed.gov), where 17142894 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17142894}}
==About this Structure==
==About this Structure==
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[[Category: McKay, D B.]]
[[Category: McKay, D B.]]
[[Category: Parallel alpha-beta]]
[[Category: Parallel alpha-beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:22:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:02:06 2008''

Revision as of 07:02, 28 July 2008

Image:2hjv.png

Template:STRUCTURE 2hjv

Structure of the second domain (residues 207-368) of the Bacillus subtilis YxiN protein

Template:ABSTRACT PUBMED 17142894

About this Structure

2HJV is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structure of the second domain of the Bacillus subtilis DEAD-box RNA helicase YxiN., Caruthers JM, Hu Y, McKay DB, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1191-5. Epub 2006 Nov 30. PMID:17142894

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