1n67

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[[Image:1n67.gif|left|200px]]
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{{Seed}}
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[[Image:1n67.png|left|200px]]
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{{STRUCTURE_1n67| PDB=1n67 | SCENE= }}
{{STRUCTURE_1n67| PDB=1n67 | SCENE= }}
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'''Clumping Factor A from Staphylococcus aureus'''
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===Clumping Factor A from Staphylococcus aureus===
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==Overview==
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We report here the crystal structure of the minimal ligand-binding segment of the Staphylococcus aureus MSCRAMM, clumping factor A. This fibrinogen-binding segment contains two similarly folded domains. The fold observed is a new variant of the immunoglobulin motif that we have called DE-variant or the DEv-IgG fold. This subgroup includes the ligand-binding domain of the collagen-binding S.aureus MSCRAMM CNA, and many other structures previously classified as jelly rolls. Structure predictions suggest that the four fibrinogen-binding S.aureus MSCRAMMs identified so far would also contain the same DEv-IgG fold. A systematic docking search using the C-terminal region of the fibrinogen gamma-chain as a probe suggested that a hydrophobic pocket formed between the two DEv-IgG domains of the clumping factor as the ligand-binding site. Mutagenic substitution of residues Tyr256, Pro336, Tyr338 and Lys389 in the clumping factor, which are proposed to contact the terminal residues (408)AGDV(411) of the gamma-chain, resulted in proteins with no or markedly reduced affinity for fibrinogen.
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The line below this paragraph, {{ABSTRACT_PUBMED_12485987}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12485987 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12485987}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:08:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:03:18 2008''

Revision as of 07:03, 28 July 2008

Image:1n67.png

Template:STRUCTURE 1n67

Clumping Factor A from Staphylococcus aureus

Template:ABSTRACT PUBMED 12485987

About this Structure

1N67 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A., Deivanayagam CC, Wann ER, Chen W, Carson M, Rajashankar KR, Hook M, Narayana SV, EMBO J. 2002 Dec 16;21(24):6660-72. PMID:12485987

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