1q56

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{{STRUCTURE_1q56| PDB=1q56 | SCENE= }}
{{STRUCTURE_1q56| PDB=1q56 | SCENE= }}
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'''NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state'''
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===NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state===
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==Overview==
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The aggregation of acetylcholine receptors on postsynaptic membranes is a key step in neuromuscular junction development. This process depends on alternatively spliced forms of the proteoglycan agrin with "B-inserts" of 8, 11, or 19 residues in the protein's globular C-terminal domain, G3. Structures of the neural B8 and B11 forms of agrin-G3 were determined by X-ray crystallography. The structure of G3-B0, which lacks inserts, was determined by NMR. The agrin-G3 domain adopts a beta jellyroll fold. The B insert site is flanked by four loops on one edge of the beta sandwich. The loops form a surface that corresponds to a versatile interaction interface in the family of structurally related LNS proteins. NMR and X-ray data indicate that this interaction interface is flexible in agrin-G3 and that flexibility is reduced by Ca(2+) binding. The plasticity of the interaction interface could enable different splice forms of agrin to select between multiple binding partners.
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{{ABSTRACT_PUBMED_15016366}}
==About this Structure==
==About this Structure==
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1Q56 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q56 OCA].
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1Q56 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q56 OCA].
==Reference==
==Reference==
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[[Category: Musk activation]]
[[Category: Musk activation]]
[[Category: Nmj synapse]]
[[Category: Nmj synapse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:52:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:03:37 2008''

Revision as of 07:03, 28 July 2008

Image:1q56.png

Template:STRUCTURE 1q56

NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state

Template:ABSTRACT PUBMED 15016366

About this Structure

1Q56 is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

Modulation of agrin function by alternative splicing and Ca2+ binding., Stetefeld J, Alexandrescu AT, Maciejewski MW, Jenny M, Rathgeb-Szabo K, Schulthess T, Landwehr R, Frank S, Ruegg MA, Kammerer RA, Structure. 2004 Mar;12(3):503-15. PMID:15016366

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