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1ov9

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{{STRUCTURE_1ov9| PDB=1ov9 | SCENE= }}
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'''Crystal structure of the N-terminal dimerisation domain of VicH, the H-NS protein from Vibrio cholerae'''
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===Crystal structure of the N-terminal dimerisation domain of VicH, the H-NS protein from Vibrio cholerae===
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==Overview==
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The histone-like nucleoid structuring (H-NS) protein is a global modulator of gene expression in Gram-negative bacteria. VicH, the H-NS protein of Vibrio cholerae, regulates the expression of certain major virulence determinants implicated in the pathogenesis of cholera. We present here the 2.5A crystal structure of the N-terminal oligomerisation domain of VicH (VicH_Nt). VicH_Nt adopts the same fold and dimeric assembly as the NMR structure of Escherichia coli H-NS_Nt, thus validating this fold against conflicting data. The structural similarity of V.cholerae VicH_Nt and E.coli H-NS_Nt, despite differences in origin, system of expression, experimental conditions and techniques used, indicates that the fold determined in our studies is robust to experimental conditions. Structural analysis and homology modelling were carried out to further elucidate the molecular basis of the functional polyvalence of the N-terminal domain. Our analysis of members of the H-NS superfamily supports the suggestion that the oligomerisation function of H-NS_Nt is conserved even in more distantly related proteins.
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{{ABSTRACT_PUBMED_14607110}}
==About this Structure==
==About this Structure==
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[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
[[Category: Helix]]
[[Category: Helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:19:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:03:57 2008''

Revision as of 07:04, 28 July 2008

Image:1ov9.png

Template:STRUCTURE 1ov9

Crystal structure of the N-terminal dimerisation domain of VicH, the H-NS protein from Vibrio cholerae

Template:ABSTRACT PUBMED 14607110

About this Structure

1OV9 is a Single protein structure of sequence from Vibrio cholerae. Full crystallographic information is available from OCA.

Reference

Crystal structure of the N-terminal dimerisation domain of VicH, the H-NS-like protein of Vibrio cholerae., Cerdan R, Bloch V, Yang Y, Bertin P, Dumas C, Rimsky S, Kochoyan M, Arold ST, J Mol Biol. 2003 Nov 21;334(2):179-85. PMID:14607110

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