1sy6

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[[Image:1sy6.gif|left|200px]]
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{{STRUCTURE_1sy6| PDB=1sy6 | SCENE= }}
{{STRUCTURE_1sy6| PDB=1sy6 | SCENE= }}
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'''Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment'''
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===Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment===
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==Overview==
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The CD3 epsilon gamma heterodimer is essential for expression and function of the T cell receptor. The crystal structure of the human CD3 epsilon gamma heterodimer is described to 2.1-A resolution complexed with OKT3, a therapeutic mAb that not only activates and tolerizes mature T cells but also induces regulatory T cells. The mode of CD3 epsilon gamma dimerization provides a general structural basis for CD3 assembly and maps candidate T cell antigen receptor docking sites, including a duplicated linear region rich in acidic residues that is unique to human CD3 epsilon. OKT3 binds to an atypically small area of CD3 epsilon and has a low affinity for the isolated CD3 epsilon gamma heterodimer. The structure of the OKT3/CD3 epsilon gamma complex has implications for T cell signaling and therapeutic design.
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(as it appears on PubMed at http://www.pubmed.gov), where 15136729 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15136729}}
==About this Structure==
==About this Structure==
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[[Category: Cd3 gamma]]
[[Category: Cd3 gamma]]
[[Category: Okt3 fab]]
[[Category: Okt3 fab]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:16:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:07:55 2008''

Revision as of 07:07, 28 July 2008

Image:1sy6.png

Template:STRUCTURE 1sy6

Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment

Template:ABSTRACT PUBMED 15136729

About this Structure

1SY6 is a Single protein structure of sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3., Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J, Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10. PMID:15136729

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