2ez6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ez6.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ez6.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ez6| PDB=2ez6 | SCENE= }}
{{STRUCTURE_2ez6| PDB=2ez6 | SCENE= }}
-
'''Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing'''
+
===Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing===
-
==Overview==
+
<!--
-
Members of the ribonuclease III (RNase III) family are double-stranded RNA (dsRNA) specific endoribonucleases characterized by a signature motif in their active centers and a two-base 3' overhang in their products. While Dicer, which produces small interfering RNAs, is currently the focus of intense interest, the structurally simpler bacterial RNase III serves as a paradigm for the entire family. Here, we present the crystal structure of an RNase III-product complex, the first catalytic complex observed for the family. A 7 residue linker within the protein facilitates induced fit in protein-RNA recognition. A pattern of protein-RNA interactions, defined by four RNA binding motifs in RNase III and three protein-interacting boxes in dsRNA, is responsible for substrate specificity, while conserved amino acid residues and divalent cations are responsible for scissile-bond cleavage. The structure reveals a wealth of information about the mechanism of RNA hydrolysis that can be extrapolated to other RNase III family members.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16439209}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16439209 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16439209}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Rna interference]]
[[Category: Rna interference]]
[[Category: Rna processing]]
[[Category: Rna processing]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:16:31 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:09:41 2008''

Revision as of 07:09, 28 July 2008

Image:2ez6.png

Template:STRUCTURE 2ez6

Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing

Template:ABSTRACT PUBMED 16439209

About this Structure

2EZ6 is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Structural insight into the mechanism of double-stranded RNA processing by ribonuclease III., Gan J, Tropea JE, Austin BP, Court DL, Waugh DS, Ji X, Cell. 2006 Jan 27;124(2):355-66. PMID:16439209

Page seeded by OCA on Mon Jul 28 10:09:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ez6"
Personal tools