2aql

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{{STRUCTURE_2aql| PDB=2aql | SCENE= }}
{{STRUCTURE_2aql| PDB=2aql | SCENE= }}
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'''Crystal Structure of the MRG15 MRG domain'''
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===Crystal Structure of the MRG15 MRG domain===
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==Overview==
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The ubiquitous MRG/MORF family of proteins is involved in cell senescence, or the terminal loss of proliferative potential, a model for aging and tumor suppression at the cellular level. These proteins are defined by the approximately 20 kDa MRG domain that binds a plethora of transcriptional regulators and chromatin-remodeling factors, including the histone deacetylase transcriptional corepressor mSin3A and the novel nuclear protein PAM14, and they are also known components of the Tip60/NuA4 complex via interactions with the MRG binding protein (MRGBP). We present here the crystal structure of a prototypic MRG domain from human MRG15 whose core consists of two orthogonal helix hairpins. Despite the lack of sequence similarity, the core structure has surprisingly striking homology to a DNA-interacting domain of the tyrosine site-specific recombinases XerD, lambda integrase, and Cre. Site-directed mutagenesis studies based on the X-ray structure and bioinformatics identified key residues involved in the binding of PAM14 and MRGBP.
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(as it appears on PubMed at http://www.pubmed.gov), where 16407074 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16407074}}
==About this Structure==
==About this Structure==
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[[Category: Mrg domain]]
[[Category: Mrg domain]]
[[Category: Recombinase]]
[[Category: Recombinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:21:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:12:55 2008''

Revision as of 07:12, 28 July 2008

Image:2aql.png

Template:STRUCTURE 2aql

Crystal Structure of the MRG15 MRG domain

Template:ABSTRACT PUBMED 16407074

About this Structure

2AQL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain., Bowman BR, Moure CM, Kirtane BM, Welschhans RL, Tominaga K, Pereira-Smith OM, Quiocho FA, Structure. 2006 Jan;14(1):151-8. PMID:16407074

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