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1p78

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[[Image:1p78.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1p78| PDB=1p78 | SCENE= }}
{{STRUCTURE_1p78| PDB=1p78 | SCENE= }}
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'''Anabaena HU-DNA cocrystal structure (AHU2)'''
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===Anabaena HU-DNA cocrystal structure (AHU2)===
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==Overview==
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HU and IHF are members of a family of prokaryotic proteins that interact with the DNA minor groove in a sequence-specific (IHF) or non-specific (HU) manner to induce and/or stabilize DNA bending. HU plays architectural roles in replication initiation, transcription regulation and site-specific recombination, and is associated with bacterial nucleoids. Cocrystal structures of Anabaena HU bound to DNA (1P71, 1P78, 1P51) reveal that while underlying proline intercalation and asymmetric charge neutralization mechanisms of DNA bending are similar for IHF and HU, HU stabilizes different DNA bend angles ( approximately 105-140 degrees ). The two bend angles within a single HU complex are not coplanar, and the resulting dihedral angle is consistent with negative supercoiling. Comparison of HU-DNA and IHF-DNA structures suggests that sharper bending is correlated with longer DNA binding sites and smaller dihedral angles. An HU-induced bend may be better modeled as a hinge, not a rigid bend. The ability to induce or stabilize varying bend angles is consistent with HU's role as an architectural cofactor in many different systems that may require differing geometries.
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(as it appears on PubMed at http://www.pubmed.gov), where 12853489 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12853489}}
==About this Structure==
==About this Structure==
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[[Category: Hu]]
[[Category: Hu]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:46:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:13:58 2008''

Revision as of 07:14, 28 July 2008

Image:1p78.png

Template:STRUCTURE 1p78

Anabaena HU-DNA cocrystal structure (AHU2)

Template:ABSTRACT PUBMED 12853489

About this Structure

1P78 is a Single protein structure of sequence from Anabaena sp.. Full crystallographic information is available from OCA.

Reference

Flexible DNA bending in HU-DNA cocrystal structures., Swinger KK, Lemberg KM, Zhang Y, Rice PA, EMBO J. 2003 Jul 15;22(14):3749-60. PMID:12853489

Page seeded by OCA on Mon Jul 28 10:13:58 2008

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