1oa5

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[[Image:1oa5.jpg|left|200px]]
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[[Image:1oa5.png|left|200px]]
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{{STRUCTURE_1oa5| PDB=1oa5 | SCENE= }}
{{STRUCTURE_1oa5| PDB=1oa5 | SCENE= }}
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'''THE SOLUTION STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT HIGH PRESSURE'''
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===THE SOLUTION STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT HIGH PRESSURE===
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==Overview==
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The solution structure of bovine pancreatic trypsin inhibitor (BPTI) at a pressure of 2 kbar is presented. The structure was calculated as a change from an energy-minimized low-pressure structure, using (1)H chemical shifts as restraints. The structure has changed by 0.24 A RMS, and has almost unchanged volume. The largest changes as a result of pressure are in the loop 10-16, which contains the active site of BPTI, and residues 38-42, which are adjacent to buried water molecules. Hydrogen bonds are compressed by 0.029 +/- 0.117 A, with the longer hydrogen bonds, including those to internal buried water molecules, being compressed more. The hydrophobic core is also compressed, largely from reduction of packing defects. The parts of the structure that have the greatest change are close to buried water molecules, thus highlighting the importance of water molecules as the nucleation sites for volume fluctuation of proteins in native conditions.
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The line below this paragraph, {{ABSTRACT_PUBMED_12930996}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12930996 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12930996}}
==About this Structure==
==About this Structure==
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1OA5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OA5 OCA].
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1OA5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OA5 OCA].
==Reference==
==Reference==
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[[Category: Williamson, M P.]]
[[Category: Williamson, M P.]]
[[Category: Protease inhibitor]]
[[Category: Protease inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:35:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:16:51 2008''

Revision as of 07:16, 28 July 2008

Image:1oa5.png

Template:STRUCTURE 1oa5

THE SOLUTION STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT HIGH PRESSURE

Template:ABSTRACT PUBMED 12930996

About this Structure

1OA5 is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

The solution structure of bovine pancreatic trypsin inhibitor at high pressure., Williamson MP, Akasaka K, Refaee M, Protein Sci. 2003 Sep;12(9):1971-9. PMID:12930996

Page seeded by OCA on Mon Jul 28 10:16:51 2008

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