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2bkd

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[[Image:2bkd.gif|left|200px]]
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{{STRUCTURE_2bkd| PDB=2bkd | SCENE= }}
{{STRUCTURE_2bkd| PDB=2bkd | SCENE= }}
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'''STRUCTURE OF THE N-TERMINAL DOMAIN OF FRAGILE X MENTAL RETARDATION PROTEIN'''
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===STRUCTURE OF THE N-TERMINAL DOMAIN OF FRAGILE X MENTAL RETARDATION PROTEIN===
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==Overview==
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FMRP, whose lack of expression causes the X-linked fragile X syndrome, is a modular RNA binding protein thought to be involved in posttranslational regulation. We have solved the structure in solution of the N-terminal domain of FMRP (NDF), a functionally important region involved in multiple interactions. The structure consists of a composite fold comprising two repeats of a Tudor motif followed by a short alpha helix. The interactions between the three structural elements are essential for the stability of the NDF fold. Although structurally similar, the two repeats have different dynamic and functional properties. The second, more flexible repeat is responsible for interacting both with methylated lysine and with 82-FIP, one of the FMRP nuclear partners. NDF contains a 3D nucleolar localization signal, since destabilization of its fold leads to altered nucleolar localization of FMRP. We suggest that the NDF composite fold determines an allosteric mechanism that regulates the FMRP functions.
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The line below this paragraph, {{ABSTRACT_PUBMED_16407062}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16407062 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16407062}}
==About this Structure==
==About this Structure==
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2BKD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKD OCA].
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2BKD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKD OCA].
==Reference==
==Reference==
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[[Category: Mrna transport]]
[[Category: Mrna transport]]
[[Category: Nuclear protein]]
[[Category: Nuclear protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:24:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:21:05 2008''

Revision as of 07:21, 28 July 2008

Image:2bkd.png

Template:STRUCTURE 2bkd

STRUCTURE OF THE N-TERMINAL DOMAIN OF FRAGILE X MENTAL RETARDATION PROTEIN

Template:ABSTRACT PUBMED 16407062

About this Structure

2BKD is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction., Ramos A, Hollingworth D, Adinolfi S, Castets M, Kelly G, Frenkiel TA, Bardoni B, Pastore A, Structure. 2006 Jan;14(1):21-31. PMID:16407062

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