2git

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[[Image:2git.gif|left|200px]]
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{{STRUCTURE_2git| PDB=2git | SCENE= }}
{{STRUCTURE_2git| PDB=2git | SCENE= }}
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'''Human Class I MHC HLA-A2 in complex with the modified HTLV-1 TAX (Y5K-4-[3-Indolyl]-butyric acid) peptide'''
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===Human Class I MHC HLA-A2 in complex with the modified HTLV-1 TAX (Y5K-4-[3-Indolyl]-butyric acid) peptide===
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==Overview==
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Although T cell receptor cross-reactivity is a fundamental property of the immune system and is implicated in numerous autoimmune pathologies, the molecular mechanisms by which T cell receptors can recognize and respond to diverse ligands are incompletely understood. In the current study we examined the response of the human T cell lymphotropic virus-1 (HTLV-1) Tax-specific T cell receptor (TCR) A6 to a panel of structurally distinct haptens coupled to the Tax 11-19 peptide with a lysine substitution at position 5 (Tax5K, LLFG[K-hapten]PVYV). The A6 TCR could cross-reactively recognize one of these haptenated peptides, Tax-5K-4-(3-Indolyl)-butyric acid (IBA), presented by HLA-A*0201. The crystal structures of Tax5K-IBA/HLA-A2 free and in complex with A6 reveal that binding is mediated by a mechanism of cooperative conformational plasticity involving conformational changes on both sides of the protein-protein interface, including the TCR complementarity determining region (CDR) loops, Valpha/Vbeta domain orientation, and the hapten-modified peptide. Our findings illustrate the complex role that protein dynamics can play in TCR cross-reactivity and highlight that T cell receptor recognition of ligand can be achieved through diverse and complex molecular mechanisms that can occur simultaneously in the interface, not limited to molecular mimicry and CDR loop shifts.
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(as it appears on PubMed at http://www.pubmed.gov), where 16962135 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16962135}}
==Disease==
==Disease==
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[[Category: Mhc class i,hla-a2]]
[[Category: Mhc class i,hla-a2]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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Revision as of 07:22, 28 July 2008

Image:2git.png

Template:STRUCTURE 2git

Contents

Human Class I MHC HLA-A2 in complex with the modified HTLV-1 TAX (Y5K-4-[3-Indolyl]-butyric acid) peptide

Template:ABSTRACT PUBMED 16962135

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

2GIT is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

T cell receptor recognition via cooperative conformational plasticity., Gagnon SJ, Borbulevych OY, Davis-Harrison RL, Turner RV, Damirjian M, Wojnarowicz A, Biddison WE, Baker BM, J Mol Biol. 2006 Oct 13;363(1):228-43. Epub 2006 Aug 22. PMID:16962135

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