1oyx

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[[Image:1oyx.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1oyx| PDB=1oyx | SCENE= }}
{{STRUCTURE_1oyx| PDB=1oyx | SCENE= }}
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'''CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (SELENO-MET) AT 1.85 ANGSTROM'''
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===CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (SELENO-MET) AT 1.85 ANGSTROM===
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==Overview==
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We report on the X-ray structure of three 100-amino acid mbt repeats in h-l(3)mbt, a polycomb group protein involved in transcriptional repression, whose gene is located in a region of chromosome 20 associated with hematopoietic malignancies. Interdigitation between the extended arms and cores of the mbt repeats results in a three-leaved propeller-like architecture, containing a central cavity. We have identified one ligand binding pocket per mbt repeat, which accommodates either the morphilino ring of MES or the proline ring of the C-terminal peptide segment, within a cavity lined by aromatic amino acids. Strikingly, phenotypic alterations resulting from point mutations or deletions in the mbt repeats of the related Drosophila SCM protein are clustered in and around the ligand binding pocket.
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(as it appears on PubMed at http://www.pubmed.gov), where 12842041 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12842041}}
==About this Structure==
==About this Structure==
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[[Category: Propeller]]
[[Category: Propeller]]
[[Category: Transcription repressor]]
[[Category: Transcription repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:26:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:25:26 2008''

Revision as of 07:25, 28 July 2008

Image:1oyx.png

Template:STRUCTURE 1oyx

CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (SELENO-MET) AT 1.85 ANGSTROM

Template:ABSTRACT PUBMED 12842041

About this Structure

1OYX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets., Wang WK, Tereshko V, Boccuni P, MacGrogan D, Nimer SD, Patel DJ, Structure. 2003 Jul;11(7):775-89. PMID:12842041

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