1xbn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1xbn.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1xbn.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1xbn| PDB=1xbn | SCENE= }}
{{STRUCTURE_1xbn| PDB=1xbn | SCENE= }}
-
'''Crystal structure of a bacterial nitric oxide sensor: an ortholog of mammalian soluble guanylate cyclase heme domain'''
+
===Crystal structure of a bacterial nitric oxide sensor: an ortholog of mammalian soluble guanylate cyclase heme domain===
-
==Overview==
+
<!--
-
Nitric oxide (NO) is extremely toxic to Clostridium botulinum, but its molecular targets are unknown. Here, we identify a heme protein sensor (SONO) that displays femtomolar affinity for NO. The crystal structure of the SONO heme domain reveals a previously undescribed fold and a strategically placed tyrosine residue that modulates heme-nitrosyl coordination. Furthermore, the domain architecture of a SONO ortholog cloned from Chlamydomonas reinhardtii indicates that NO signaling through cyclic guanosine monophosphate arose before the origin of multicellular eukaryotes. Our findings have broad implications for understanding bacterial responses to NO, as well as for the activation of mammalian NO-sensitive guanylyl cyclase.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15472039}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15472039 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15472039}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Nitric oxide]]
[[Category: Nitric oxide]]
[[Category: Soluble guanylyl cyclase]]
[[Category: Soluble guanylyl cyclase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:49:21 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:26:20 2008''

Revision as of 07:26, 28 July 2008

Image:1xbn.png


PDB ID 1xbn

Drag the structure with the mouse to rotate
1xbn, resolution 2.50Å ()
Ligands: ,
Gene: Tar4 (Thermoanaerobacter tengcongensis MB4)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal structure of a bacterial nitric oxide sensor: an ortholog of mammalian soluble guanylate cyclase heme domain

Template:ABSTRACT PUBMED 15472039

About this Structure

1XBN is a Single protein structure of sequence from Thermoanaerobacter tengcongensis. Full crystallographic information is available from OCA.

Reference

Femtomolar sensitivity of a NO sensor from Clostridium botulinum., Nioche P, Berka V, Vipond J, Minton N, Tsai AL, Raman CS, Science. 2004 Nov 26;306(5701):1550-3. Epub 2004 Oct 7. PMID:15472039

Page seeded by OCA on Mon Jul 28 10:26:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xbn"
Personal tools